Blood flow, oxygen consumption and tissue oxygenation of human tumors

Advances in Experimental Medicine and Biology
P VaupelP Okunieff

Abstract

The objective of this article was to summarize current knowledge of blood flow and oxygen supply to human tumors, parameters which go hand in hand, and in turn critically determine the cellular metabolic microenvironment of human malignancies. A compilation of available data on blood flow, oxygen supply, and tissue oxygen distribution in human tumors is presented. Though data on human tumors in situ are scarce and there may be significant errors associated with the techniques used for measurements, experimental evidence is provided for the existence of a compromised and anisotropic blood supply to many tumors. Comparable to rodent tumors, O2-depleted areas develop in human malignancies which coincide with nutrient and energy deprivation, and with a hostile metabolic microenvironment. Significant variations in these relevant parameters have to be expected between different locations within the same tumor, at the same location at different times, and between individual tumors of the same grading and staging.

Citations

Nov 15, 2006·World Journal of Surgery·Jurstine Daruwalla, Chris Christophi
Mar 11, 2008·Angiogenesis·Guo-Hua Fong
Jan 15, 2008·Breast Cancer Research : BCR·Stephen B FoxAdrian L Harris
Dec 12, 2017·Proteomics. Clinical Applications·Mitchell AclandPeter Hoffmann
Apr 9, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M WartenbergH Sauer
Jun 4, 2010·The Journal of Pharmacology and Experimental Therapeutics·Fabio CianchiLuca Puccetti
Apr 7, 2007·Cancer Metastasis Reviews·Pawel SwietachAdrian L Harris
Jun 24, 2018·Cells·Gianluca SgarbiAlessandra Baracca
Mar 12, 2015·Technology in Cancer Research & Treatment·Nils D ArvoldUmar Mahmood
Aug 15, 2008·Cancer Research·Benoit Ho-Tin-NoéDenisa D Wagner
Oct 1, 1991·Journal of Photochemistry and Photobiology. B, Biology·I Freitas, G F Baronzio
Jan 19, 2002·Differentiation; Research in Biological Diversity·C MailhosD Ish-Horowicz
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Dietmar W Siemann, Amyn M Rojiani
Apr 27, 2005·International Journal of Radiation Oncology, Biology, Physics·Nils D ArvoldDaphne A Haas-Kogan
Jul 4, 2018·Chemical Reviews·Toktam NezakatiAlexander M Seifalian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Related Papers

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
P Vaupel
Transfusion clinique et biologique : journal de la Société française de transfusion sanguine
P Vaupel, Arnulf Mayer
Journal of Magnetic Resonance Imaging : JMRI
Robert J GilliesZaver M Bhujwalla
International Journal of Cancer. Journal International Du Cancer
Erzsébet Papp-SzabóBrenda L Coomber
© 2021 Meta ULC. All rights reserved