Blood-flow restricted resistance training in patients with sporadic inclusion body myositis: a randomized controlled trial

Scandinavian Journal of Rheumatology
A N JørgensenL P Diederichsen

Abstract

To investigate the effect of 12 weeks of low-load blood-flow restricted resistance (BFR) training on self-reported and objective physical function, and maximal muscle strength in patients with sporadic inclusion body myositis (sIBM). Twenty-two patients with sIBM were randomized into a training group (BFR group) or a non-exercising control group, according to CONsolidated Standards Of Reporting Trials (CONSORT) guidelines. The BFR group performed 12 weeks of BFR training twice per week. The primary outcome was the physical function domain of the 36-item Short Form Health Survey (pf-SF-36), which was used to measure self-reported physical function. All patients performed physical function tests (2-Minute Walk Test, Timed Up and Go, and 30-Second Chair Stand), completed the Inclusion Body Myositis Functional Rating Scale (IBMFRS), and were tested for isolated knee extensor muscle strength. No effects of the training intervention were observed for pf-SF-36 or the objective physical function tests. Leg muscle strength decreased in controls (-9.2%, p = 0.02), but was unaltered in the BFR group (+0.9%, p = 0.87), resulting in a between-group difference in the per-protocol analysis (p = 0.026). Between-group differences in baseline to...Continue Reading

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Citations

Feb 8, 2020·Scandinavian Journal of Medicine & Science in Sports·Birk Mygind GrønfeldtPer Aagaard
Jul 24, 2018·Current Treatment Options in Neurology·Namita A Goyal, Tahseen Mozaffar
Jan 8, 2019·Current Treatment Options in Rheumatology·Helene Alexanderson
Mar 13, 2020·Current Reviews in Musculoskeletal Medicine·Johnny G OwensDustin Nabhan
Jun 28, 2019·Orphanet Journal of Rare Diseases·Naoki SuzukiMasashi Aoki
Sep 10, 2019·Frontiers in Physiology·Matthew J ClarksonStuart A Warmington
Apr 13, 2021·Arthritis & Rheumatology·Ingrid E Lundberg
Aug 31, 2021·Current Opinion in Rheumatology·Alexandre Moura Dos SantosSamuel Katsuyuki Shinjo
Oct 13, 2021·Scandinavian Journal of Medicine & Science in Sports·Anders N JørgensenPer Aagaard

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