Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial

Journal of Clinical Medicine
Sara A HarperThomas W Buford

Abstract

In a pilot randomized clinical trial, participants aged ≥60 years (n = 35) with physical limitations and symptomatic knee osteoarthritis (OA) were randomized to 12 weeks of lower-body low-load resistance training with blood-flow restriction (BFR) or moderate-intensity resistance training (MIRT) to evaluate changes in muscle strength, pain, and physical function. Four exercises were performed three times per week to volitional fatigue using 20% and 60% of one repetition maximum (1RM). Study outcomes included knee extensor strength, gait speed, Short Physical Performance Battery (SPPB) performance, and pain via the Western Ontario and McMaster Universities OA Index (WOMAC). Per established guidance for pilot studies, primary analyses for the trial focused on safety, feasibility, and effect sizes/95% confidence intervals of dependent outcomes to inform a fully-powered trial. Across three speeds of movement, the pre- to post-training change in maximal isokinetic peak torque was 9.96 (5.76, 14.16) Nm while the mean difference between groups (BFR relative to MIRT) was -1.87 (-10.96, 7.23) Nm. Most other directionally favored MIRT, though more spontaneous reports of knee pain were observed (n = 14) compared to BFR (n = 3). BFR may hav...Continue Reading

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Citations

Nov 7, 2019·Journal of Clinical Medicine·David Scott
Oct 28, 2019·Journal of Clinical Medicine·David RicePatrick Finan
Feb 15, 2021·Physical Therapy in Sport : Official Journal of the Association of Chartered Physiotherapists in Sports Medicine·Brayden GranthamKieran O'Sullivan
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Mar 18, 2021·American Journal of Physical Medicine & Rehabilitation·Shuoqi LiMohammed Rafiq Abdul Kadir
May 4, 2021·Physical Therapy in Sport : Official Journal of the Association of Chartered Physiotherapists in Sports Medicine·Jun Seob SongJeremy P Loenneke
Aug 16, 2021·Journal of Bodywork and Movement Therapies·Alexios PitsillidesIoannis Mamais

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays

Clinical Trials Mentioned

NCT02132715

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