PMID: 8964951Mar 7, 1996Paper

Blood-flow sensing by anionic biopolymers

Journal of the Autonomic Nervous System
G SiegelA Kauschmann

Abstract

Using 23Na-NMR techniques we could show that the polyanion proteoheparan sulfate integrated into the membrane of endothelial cells may serve as "flow sensor'. Based on its viscoelastic properties, heparan sulfate proteoglycan is present as a random coil under "no flow' conditions, whereby most of its polyanionic sites undergo intramolecular hydrogen bonding. With increasing flow the macromolecule becomes unfolded into a filamentous structure. Additional anionic binding sites to which Na+ ions from the blood bind are released by this shear stress-dependent conformational change. The Na+ binding triggers the signal transduction chain for a vasodilatory vessel reaction. Decrease in flow effects, for reasons of the intramolecular elastic recoil forces of the macromolecules, an entropic coiling, the release of Na+ ions and thus an interruption of the signal chain. Proteoheparan sulfate adsorbed onto a hydrophobic surface in physiological Krebs solution at pH 7.3 demonstrated clearly its characteristic as a Na+ sensor. While Ca2+ ions modulated the adsorption (promotion with increasing Ca2+ concentrations) by changing the conformation of the sensor molecule, the adsorbed amount was determined preferably by the Na+ concentration. K+ a...Continue Reading

References

Jan 1, 1992·Journal of Cardiovascular Pharmacology·G SiegelJ Grote
Sep 18, 1981·Biochimica Et Biophysica Acta·H GustavssonL A Fransson
Jul 1, 1993·Acta Physiologica Scandinavica·V M KhayutinE V Lukoshkova

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Citations

Mar 22, 2007·Annual Review of Biomedical Engineering·Sheldon WeinbaumEdward R Damiano
Nov 1, 2012·F1000 Biology Reports·Kristina Kusche-Vihrog, Hans Oberleithner
Jan 31, 2015·Journal of the American College of Cardiology·Petra NijstWilfried Mullens
May 1, 2007·Journal of the American Society of Hypertension : JASH·Michel E SafarGérard E Plante
Apr 6, 2006·Journal of Internal Medicine·J M Tarbell, M Y Pahakis
Jul 17, 2014·Pflügers Archiv : European journal of physiology·Hans Oberleithner
Oct 8, 2016·Annual Review of Cell and Developmental Biology·Guillermo García-Cardeña, Bendix R Slegtenhorst
Feb 20, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·G SiegelW Schneider
Sep 4, 2015·Lab on a Chip·Jonathan ShemeshMajid Ebrahimi Warkiani
Oct 18, 2011·Vascular Medicine·Blair D JohnsonJanet P Wallace
Apr 27, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Xi Zhuo JiangKai H Luo
Dec 5, 1998·Microscopy Research and Technique·G SiegelD Klüssendorf
Jan 13, 2000·International Journal of Experimental Pathology·P Vallance, A Hingorani
Aug 24, 2004·Journal of Applied Physiology·Kristy M AinslieJohn M Tarbell
Feb 25, 2017·Current Heart Failure Reports·Youn-Hyun KimW H Wilson Tang
Sep 25, 2001·Journal of Applied Physiology·S M Dudek, J G Garcia

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