Blood flow switching among pulmonary capillaries is decreased during high hematocrit

Journal of Applied Physiology
William A BaumgartnerWiltz W Wagner

Abstract

Pulmonary capillary perfusion within a single alveolar wall continually switches among segments, even when large-vessel hemodynamics are constant. The mechanism is unknown. We hypothesize that the continually varying size of plasma gaps between individual red blood cells affects the likelihood of capillary segment closure and the probability of cells changing directions at the next capillary junction. We assumed that an increase in hematocrit would decrease the average distance between red blood cells, thereby decreasing the switching at each capillary junction. To test this idea, we observed 26 individual alveolar capillary networks by using videomicroscopy of excised canine lung lobes that were perfused first at normal hematocrit (31-43%) and then at increased hematocrit (51-62%). The number of switches decreased by 38% during increased hematocrit (P < 0.01). These results support the idea that a substantial part of flow switching among pulmonary capillaries is caused by the particulate nature of blood passing through a complex network of tubes with continuously varying hematocrit.

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Citations

May 15, 2013·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·K P Ivanov
Sep 3, 2010·PloS One·Zackary I ClevelandBastiaan Driehuys
Jun 25, 2010·Nitric Oxide : Biology and Chemistry·Claire de BisschopHervé Guénard
Jul 28, 2015·Biochimica Et Biophysica Acta·Andrew E EkpenyongJochen Guck
Nov 12, 2014·The Journal of Physiology·Jefferson C FrisbeePaul D Chantler
Dec 21, 2018·Journal of Applied Physiology·Wiltz W WagnerRobert G Presson
Jan 3, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Naoki MiyaoKazuhiro Yamaguchi

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