PMID: 11902334Mar 21, 2002Paper

Blood gammadelta T cells and gammadelta TCR V gene specificities in a single missense mutation (L-->Q271) in the common gamma chain gene

Scandinavian Journal of Immunology
F C SchmalstiegA S Goldman

Abstract

The numbers of blood CD4+, CD8+, and CD4-CD8- T cells bearing alphabeta T-cell receptor (TCR) or gammadelta TCR molecules in males with a single missense mutation (L-->Q271) in the common gamma chain gene (gamma(c)) were investigated by flow cytometry. Virtually all XCIDL-->Q271 blood T cells that were CD4+ or CD8+ displayed alphabeta TCR but no gammadelta TCR. In contrast, CD4-CD8- T cells from affected males usually displayed gammadelta TCR, but no alphabeta TCR. The gammadelta TCR specificities were also studied. Except for the oldest subject, there was a direct relationship between blood CD3+ T cells that displayed gammadelta TCR and Vgamma9 and Vdelta2a specificities. Relative frequencies of CD3+ blood T cells that were Vgamma9+ or Vdelta2a+ were inversely related to age. In the oldest patient, the only detected gammadelta TCR specificity was Vdelta1. Thus, in contrast to mice with no gamma(c), XCIDL-Q271 blood T cells that bear gammadelta TCR with Vgamma9/Vdelta2a specificities develop but then decline in late childhood and thereafter. TCR with the Vdelta1 specificity then appear in older survivors with XCIDL-->Q271.

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Mar 21, 2002·Scandinavian Journal of Immunology·A S GoldmanF C Schmalstieg

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Citations

Jul 20, 2002·Molecular Genetics and Metabolism·Frank C Schmalstieg, Armond S Goldman
Jul 9, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Andrew M HebbelerC David Pauza
Jan 11, 2012·Veterinary Immunology and Immunopathology·Stefan M Keller, Peter F Moore
Jul 27, 2021·Current Opinion in Oncology·Nuria KoteckiAhmad Awada

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