Blood Genome-Wide Transcriptional Profiles of HER2 Negative Breast Cancers Patients

Mediators of Inflammation
Ovidiu BalacescuIoana Berindan-Neagoe

Abstract

Tumors act systemically to sustain cancer progression, affecting the physiological processes in the host and triggering responses in the blood circulating cells. In this study, we explored blood transcriptional patterns of patients with two subtypes of HER2 negative breast cancers, with different prognosis and therapeutic outcome. Peripheral blood samples from seven healthy female donors and 29 women with breast cancer including 14 triple-negative breast cancers and 15 hormone-dependent breast cancers were evaluated by microarray. We also evaluated the stroma in primary tumors. Transcriptional analysis revealed distinct molecular signatures in the blood of HER2- breast cancer patients according to ER/PR status. Our data showed the implication of immune signaling in both breast cancer subtypes with an enrichment of these processes in the blood of TNBC patients. We observed a significant alteration of "chemokine signaling," "IL-8 signaling," and "communication between innate and adaptive immune cells" pathways in the blood of TNBC patients correlated with an increased inflammation and necrosis in their primary tumors. Overall, our data indicate that the presence of triple-negative breast cancer is associated with an enrichment of...Continue Reading

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Citations

Aug 23, 2020·International Journal of Molecular Sciences·Maria-Ancuta JurjIoana Berindan-Neagoe

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Methods Mentioned

BETA
Feature Extraction
PCR

Software Mentioned

IPA Upstream Regulator Analysis
Ingenuity Knowledge Base
Ingenuity Pathway Analysis
Roche
Feature Extraction
IPA Core
Applied Science
IPA
Gene Spring GX
Core Analysis

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