Blood glucose and coronary artery disease in nondiabetic patients

Diabetes Care
Christopher NielsonNicholas Hadjokas

Abstract

Nondiabetic patients were studied to determine whether modest elevations in blood glucose may be associated with a greater incidence of coronary artery disease (CAD). Baseline morning blood glucose determinations were evaluated with respect to subsequent coronary disease using records from 24,160 nondiabetic patients. CAD was identified from myocardial infarction, new diagnoses of angina, or new prescriptions for nitroglycerin that occurred more than a year after baseline glucose determinations. Of 24,160 patients studied, 3,282 patients developed CAD over a total analysis time at risk of 77,048 years. Higher baseline morning glucose (100-126 vs. <100 mg/dl) was associated with a 53.9% greater myocardial infarction incidence rate, an 18.6% greater acute coronary syndrome incidence rate, and a 26.4% greater number of new prescriptions for nitrates (all P < 0.05). A Cox proportional hazards model with adjustment for age, BMI, sex, creatinine, lipids, smoking, and medications showed that elevated fasting glucose was associated with an increased hazard for new CAD (hazard ratio 1.13 [95% CI 1.05-1.21], glucose >100 vs. <100 mg/dl). Kaplan-Meier analysis showed that elevated baseline glucose was associated with a progressive increas...Continue Reading

Citations

May 16, 2008·Journal of Human Hypertension·A K GuptaF Halberg
Nov 13, 2008·Annals of Family Medicine·Richelle J KoopmanRickey E Carter
Dec 19, 2013·Indian Dermatology Online Journal·Lata SharmaAruna Agrawal
May 15, 2013·Journal of Diabetes Research·Lulu WangNingning Dang
Nov 3, 2012·International Journal of Hypertension·Maguy ChihaEdgar G Chedrawy
Jan 14, 2012·Cardiology Research and Practice·Martin ThoenesDavid Spirk
Jun 18, 2019·Journal of Public Health·Alexander B BarkerRachael L Murray

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.