Blood Glucose and Insulin Concentrations after Octreotide Administration in Horses With Insulin Dysregulation

Journal of Veterinary Internal Medicine
N FrankC K Uricchio

Abstract

Octreotide is a somatostatin analog that suppresses insulin secretion. We hypothesized that octreotide would suppress insulin concentrations in horses and that normal (N) horses and those with insulin dysregulation (ID) would differ significantly in their plasma glucose and insulin responses to administration of octreotide. Twelve horses, N = 5, ID = 7. Prospective study. An oral sugar test was performed to assign horses to N and ID groups. Octreotide (1.0 μg/kg IV) was then administered, and blood was collected at 0, 5, 10, 15, 20, 25, 30, 45, 60, 75, and 90 minute, and 2, 3, 4, 6, 8, 12, and 24 hour for measurement of glucose and insulin concentrations. Area under the curve (AUC) values were calculated. Mean AUC values for glucose and insulin did not differ between normal (n = 5) and ID (n = 7) groups after octreotide injection. Significant time (P < .001) effects were detected for glucose and insulin concentrations. A group × time interaction (P = .091) was detected for insulin concentrations after administration of octreotide, but the group (P = .33) effect was not significant. Octreotide suppresses insulin secretion, resulting in hyperglycemia, and then concentrations increase above baseline as glycemic control is restored...Continue Reading

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y YamadaS Seino
Jun 1, 1986·Clinical Endocrinology·R R DaviesD G Johnston
Apr 1, 1995·The Journal of Small Animal Practice·K W SimpsonC R Vaillant
Aug 6, 1999·Frontiers in Neuroendocrinology·Y C Patel
Mar 7, 2003·Theriogenology·Jörg E AurichChristine Aurich
Aug 28, 2007·The Veterinary Journal·Katie E AsplinCatherine M McGowan
Dec 11, 2007·Equine Veterinary Journal·A M Firshman, S J Valberg
Jan 29, 2008·Molecular and Cellular Endocrinology·Leo J Hofland
Sep 20, 2008·Domestic Animal Endocrinology·L I SlingerlandH S Kooistra
Feb 17, 2010·Equine Veterinary Journal·M A de LaatC C Pollitt
Apr 14, 2010·Journal of Veterinary Internal Medicine·N FrankUNKNOWN American College of Veterinary Internal Medicine
May 7, 2015·Journal of Veterinary Internal Medicine·C J ScudderS J M Niessen
May 29, 2015·Drugs·Kate McKeage
Jul 29, 2015·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Melissa F BreretonAnne Clark
Apr 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mengxin WangTao Gong

❮ Previous
Next ❯

Citations

Jul 22, 2019·Journal of Veterinary Pharmacology and Therapeutics·Daniela LuethyJames Anthony Orsini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.