Blood glucose control during selective arterial stimulation and venous sampling for localization of focal hyperinsulinism lesions in anesthetized children.

Anesthesia and Analgesia
Giovanni CucchiaroMehernoor F Watcha

Abstract

Surgical management of congenital hyperinsulinism is improved by accurate localization of small, focal dysregulated pancreatic lesions using the arterial stimulation and venous sampling (ASVS) test, which can demonstrate increased hepatic venous insulin concentrations after selective arterial injections of calcium. However, anesthesia-related increases in blood glucose can induce insulin secretion, making it difficult to interpret ASVS test data. In this retrospective study, we examined the effect of anesthetic interventions on blood glucose concentrations in 68 children undergoing ASVS testing. We considered only the glucose concentrations observed before calcium stimulation in the final analysis. The choice of drugs for induction (sevoflurane, propofol, or thiopentone), maintenance inhaled anesthetics (sevoflurane, desflurane, or isoflurane), and the use of caudal epidural bupivacaine were not associated with significant differences in the mean blood glucose concentration before ASVS. However, patients receiving remifentanil infusions had smaller mean glucose concentrations (80 +/- 18 versus 100 +/- 44 mg x dl(-1), P = 0.01). These concentrations were also significantly smaller if tracheal intubation was delayed for at least ...Continue Reading

References

Aug 1, 1990·Anesthesiology·C Weissman
Jan 1, 1988·International Anesthesiology Clinics·K J Anand, M P Ward-Platt
Aug 1, 1986·Journal of Pediatric Surgery·G SrinivasanC R Kannan
Feb 1, 1985·Journal of Pediatric Surgery·K J AnandA Aynsley-Green
Jun 1, 1993·British Journal of Anaesthesia·A R WolfL Simon
Apr 15, 1999·The New England Journal of Medicine·P de Lonlay-DebeneyJ M Saudubray
Oct 8, 1999·Anesthesia and Analgesia·Peter S A GlassScott Howell
Feb 24, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·A Aynsley-GreenK J Lindley
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Charles A Stanley
Jan 23, 2003·Anesthesia and Analgesia·Ralph LattermannThomas Schricker
Mar 22, 2003·Acta Anaesthesiologica Scandinavica·K MyreO Stokland

❮ Previous
Next ❯

Citations

Mar 7, 2007·CNS Drugs·Srinivas Pyati, Tong J Gan
Oct 1, 2008·PET Clinics·Mohamed HouseniAbass Alavi
May 27, 2009·Annales Françaises D'anesthèsie Et De Rèanimation·V BillardM-L Raffin-Sanson
Jun 15, 2007·Paediatric Anaesthesia·Olga T Hardy, Ronald S Litman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.