Blood glucose determination: plasma or serum?

Journal of Clinical Laboratory Analysis
Elizebeth A FrankCletus J M D'Souza

Abstract

Blood glucose determination is one of the most common clinical diagnostic tests. Often, blood is collected in a field station and analysis is carried out in a remote laboratory. Because blood cells can continue to metabolize glucose, the time of determination of blood glucose after drawing the blood is important. In order to test the relative suitability of plasma and serum for blood glucose determination, fluoride plasma and Ethylene Diamine Tetra Acetic acid (EDTA) plasma were compared with the serum of the same patient. The analyses were carried out within 10 min of drawing the blood and, thereafter, with a gap of 4 hr and 8 hr. Serum gave values lower than fluoride plasma by 1.15%. Although this difference was statistically significant, it may not be physiologically relevant. Hence, serum may be used for blood glucose determination with an error of 1.15%. On storing the sample at room temperature for 8 hr, the serum glucose value decreased by 8%. Even fluoride plasma had 4.3% lower glucose. Hence, blood glucose should be determined within as short a time as possible after drawing the blood.

References

Jun 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·C V OverfieldM G Heintges
Jun 1, 2005·Seminars in Fetal & Neonatal Medicine·Sanjeev Deshpande, Martin Ward Platt
Jun 7, 2006·Current Biology : CB·Akhilesh B ReddyMichael H Hastings
Feb 13, 2008·Clinical Chemistry·Raymond Gambino
Aug 1, 2009·Diabetes Research and Clinical Practice·Daniela ElleriRoman Hovorka

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Citations

Oct 29, 2013·Annual Review of Pharmacology and Toxicology·Christopher LaustedKai Wang
Sep 14, 2015·Analytical and Bioanalytical Chemistry·Hilal TorulUğur Tamer
Aug 25, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·H MalmströmN Hammar
Apr 15, 2016·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ditte SteinicheUNKNOWN Bissau HIV Cohort study group
Jul 9, 2014·Annals of Clinical Biochemistry·Goce DimeskiNigel N Brown
Jan 29, 2017·The Journal of Endocrinology·Ulrika BergströmIda A K Nilsson
Sep 5, 2020·Clinical Medicine Insights. Endocrinology and Diabetes·Mohammed AbusaibAbbas Mansour
May 5, 2017·Scientific Reports·Judith SchwartzbaumMaria Feychting
May 8, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Rubén Gómez RiojaVirtudes Álvarez

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