Blood graft composition and post-transplant recovery in myeloma patients mobilized with plerixafor: a prospective multicenter study

Leukemia & Lymphoma
Jaakko ValtolaVille Varmavuo

Abstract

The composition of autologous blood grafts after cryopreservation, post-transplant hematological recovery up to 1 year and immune recovery up to 6 months as well as outcome was analyzed in 87 patients with multiple myeloma (MM). The patients receiving added plerixafor due to poor mobilization (11%) were compared to those mobilized with G-CSF or cyclophosphamide (CY) plus G-CSF. The use of plerixafor was found to significantly affect the graft composition as there was a significantly higher proportion of the more primitive CD34+ cells, higher number of T and B lymphocytes as well as NK cells in the grafts of patients who received also plerixafor. The hematological recovery after auto-SCT was comparable between the groups. The recovery of CD3+CD4+ T cells was faster in plerixafor mobilized patients at 1 and 3 months post-transplant. There were no significant differences in progression-free (PFS) or overall survival (OS) according to the plerixafor use.

References

Dec 27, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Devendra K HiwaseAnthony P Schwarer
Aug 30, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Iskra PusicJohn F DiPersio
Apr 28, 2012·European Journal of Haematology·Ville VarmavuoEsa Jantunen
Feb 6, 2013·Theranostics·Bikash DebnathNouri Neamati
Jul 22, 2014·Bone Marrow Transplantation·A L GarfallE A Stadtmauer
Sep 1, 2016·Journal of Clinical Apheresis·Nina WorelHildegard T Greinix
Feb 8, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ivana N MicallefJohn F DiPersio
Mar 16, 2018·Bone Marrow Transplantation·Jakob R PasswegUNKNOWN European Society for Blood and Marrow Transplantation (EBMT)

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