PMID: 2497072May 15, 1989Paper

Blood group ABH-related antigens in normal and malignant bladder urothelium: possible structural basis for the deletion of type-2 chain ABH antigens in invasive carcinomas

International Journal of Cancer. Journal International Du Cancer
T F OrntoftS Hakomori

Abstract

A complete panel of mouse monoclonal antibodies (MAbs) against Type-2 chain (GaI beta I-4GlcNAc-R) blood-group antigens (N-acetyl-lactosamine, Lex, H, Ley, A monofucosylated, Aley, repetitive A) was used in a detailed immunohistological study of the modulation of these carbohydrate antigens in transitional-cell carcinomas. The histological and cellular locations of these antigens were studied in 19 normal bladder biopsies and 53 transitional-cell carcinomas with as well as without neuraminidase treatment of tissue sections in order to uncover potential sialylated antigens. The antigen expression was correlated to individual A1A2BO, Lewis, and secretor status. Several alterations of blood group expression were found: (1) loss of A and H antigens with accumulation of Ley antigens; (2) loss of correlation between antigen expression and secretor status; (3) disruption of the orderly stratification of blood-group antigen expression in relation to cell layers; and (4) changes in subcellular location of antigen expression. The present data indicate that deletion of Type-2 chain ABH antigens in transitional-cell carcinomas is associated with alpha 1-3 fucosylation of the H antigen leading to accumulation of Ley antigens.

References

Jan 1, 1986·Vox Sanguinis·R OriolR Mollicone
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H ClausenS Hakomori
Sep 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E DabelsteenJ Reibel
Jun 15, 1984·International Journal of Cancer. Journal International Du Cancer·A BrownJ D Hardcastle
May 15, 1982·British Medical Journal·M C Bishop
Oct 10, 1980·Science·D R Howard, J G Batsakis
Jan 1, 1981·Annual Review of Biochemistry·S Hakomori
Sep 1, 1982·Urology·B S Stein, A R Kendall

❮ Previous
Next ❯

Citations

Jun 1, 1997·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S L Graziano
Aug 26, 1998·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S A MehdiS L Graziano
Apr 12, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J Le PenduM Clément
May 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E Dabelsteen, G K Jacobsen
Jun 1, 1996·Clinical Molecular Pathology·F Dall'olio
Jan 31, 2009·Acta Histochemica Et Cytochemica·Aki TanakaFukumi Furukawa
Sep 13, 2008·Diagnostic Pathology·Ernesto Moro-Rodríguez, Emilio Alvarez-Fernández
Sep 18, 2002·Cancer Cell International·Malgorzata PrzybyloPiotr Laidler
Apr 9, 2008·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Andreas KuemmelRainer Wiewrodt
Apr 29, 1998·The Journal of Urology·R G AarninkH Wijkstra
Dec 15, 1990·International Journal of Cancer. Journal International Du Cancer·Y FradetL Bernier
Feb 1, 1992·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·Y KominatoT Suzuki
Jan 21, 1991·International Journal of Cancer. Journal International Du Cancer·G PancinoY Najean
Jul 1, 1992·Revue française de transfusion et d'hémobiologie : bulletin de la Société nationale de transfusion sanguine·P Gane, P Rouger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.