Blood group isoantibody stimulation in man by feeding blood group-active bacteria

The Journal of Clinical Investigation
G F Springer, R E Horton

Abstract

It was investigated whether or not the human blood group isoantibodies A and B could be induced by immunogenic stimuli via natural routes with a kind of antigenic substance to which all humans are commonly exposed, or if the appearance of these antibodies is independent of antigenic stimuli as has long been believed. Escherichia coli O(86), which possess high human blood group B and faint A activity in vitro, were fed to healthy humans and those with intestinal disorders. 80% of the sick individuals of blood group O and A responded with a significant rise of anti-B antibodies which was frequently de novo in infants; significant increase of anti-A isoantibodies among blood group O individuals was less frequent. Over one-third of the healthy individuals also had a significant isoantibody increase. Intestinal lesions favor isoantibody stimulation by intestinal bacteria; this view was supported by the study of control infants. Persons of blood group A responded more frequently with anti-B and anti-E. coli O(86) antibody production than those of blood group O. Isoantibody increase was accompanied with antibody rise against E. coli O(86). Inhalation of E. coli O(86) or blood group AH(O)-specific hog mucin also evoked isoantibodies. T...Continue Reading

References

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Citations

Jan 1, 1979·Journal of Surgical Oncology·G F SpringerE F Scanlon
Jan 1, 1972·Humangenetik·G Kellermann
Mar 1, 1981·Die Naturwissenschaften·G F Springer, H Tegtmeyer
Jun 1, 1980·Die Naturwissenschaften·G F Springer, H Tegtmeyer
Nov 18, 2006·Applied Microbiology and Biotechnology·Gang-Liang HuangPeng-George Wang
Jun 1, 1988·Transfusion Medicine Reviews·U Galili
Jan 16, 1998·Immunology and Cell Biology·N J WuttkeH Zola
Nov 2, 2004·Nature Medicine·Jagdeep S Obhrai, Fadi G Lakkis
Mar 15, 2001·The New England Journal of Medicine·L J WestJ G Coles
Dec 4, 2010·The Journal of Biological Chemistry·Paul A PolandRebecca P Hughey
Jan 25, 2008·The Journal of Biological Chemistry·Sean R StowellRichard D Cummings
Feb 16, 2006·Transplantation·Helen FerryRichard J Cornall
Aug 6, 2004·Proceedings. Biological Sciences·Robert M SeymourKenth Gustafsson
Jul 6, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Craig J TaylorJ Andrew Bradley
Jul 1, 1971·Vox Sanguinis·G GarrattyL D Petz
Mar 1, 1974·Vox Sanguinis·G F Springer, H Tegtmeyer
Oct 1, 1994·Immunological Reviews·D K CooperR Oriol
Oct 18, 2011·Biochemistry. Biokhimii︠a︡·N V ShilovaN V Bovin
May 1, 1981·The British Journal of Ophthalmology·H AvakianA Ebringer
Feb 2, 2013·Circulation Research·Patricia E de AlmeidaJoseph C Wu
Aug 1, 1978·The Journal of Clinical Investigation·G N GrossA K Pierce
Dec 1, 1993·The Journal of Clinical Investigation·L C JefferiesL E Silberstein

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