Blood group related antigens in ocular cicatricial pemphigoid

The British Journal of Ophthalmology
C Creuzot-GarcherJ Bara

Abstract

To study the MUC5AC and the blood group related antigen expression in ocular cicatricial pemphigoid (OCP) according to the distribution of Lewis and secretor phenotypes in OCP patients compared to normal subjects. Immunostaining was performed on conjunctival biopsy specimens from 22 consecutive patients suffering from OCP, using monoclonal antibodies (Mabs) directed against the peptidic core MUC5AC mucin (anti-M1/MUC5AC Mabs) and against the saccharide moieties (anti-blood group related antigens). These latter included anti-Le(a), anti-Le(b), anti-sialyl Le(a), and H type 2 Mabs, which immunoreact with Lewis positive and non-secretor (Le(a)), Lewis positive and secretor (Le(b)), Lewis positive (sialyl Le(a)), and secretor (H type 2) phenotypes respectively. Serological tests were also performed to confirm the phenotype of each patient. The immunohistopathological patterns and the distribution of Lewis and secretor phenotypes were compared with the results of a previous study in normal individuals. (1) In OCP patients compared to the normal population, anti-M1 immunoreactivity of goblet cells was unchanged, whereas anti-Le(a), anti-Le(b), and anti-sialyl Le(a) immunoreactivities of epithelial and/or goblet cells were markedly de...Continue Reading

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Citations

Mar 13, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·E SchmidtG Geerling
Sep 22, 2005·Current Opinion in Ophthalmology·Margherita E Eschle-MeniconiC Stephen Foster
Jul 28, 2015·Clinical and Experimental Dermatology·M Shahidi-Dadras, A Golfeshan
Aug 5, 2016·Clinical and Experimental Dermatology·M S Dadras, A Golfeshan
Jul 21, 2016·Dermatology Research and Practice·Sedigheh BakhtiariNasrin Rafieian
Aug 27, 2019·Therapeutic Advances in Ophthalmology·Tanima Bose

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