Blood Groups Distribution and Gene Diversity of the ABO and Rh (D) Loci in the Mexican Population

BioMed Research International
Adrián Canizalez-RománJonathan Alcántar-Fernández

Abstract

To determine the frequency and distribution of ABO and Rh (D) antigens and, additionally, investigate gene diversity and the structure of Mexican populations. Blood groups were tested in 271,164 subjects from 2014 to 2016. The ABO blood group was determined by agglutination using the antibodies anti-A, Anti-B, and Anti-D for the Rh factor, respectively. The overall distribution of ABO and Rh (D) groups in the population studied was as follows: O: 61.82%; A: 27.44%; B: 8.93%; and AB: 1.81%. For the Rh group, 95.58% of people were Rh (D), and 4.42% were Rh (d). Different distributions of blood groups across regions were found; additionally, genetic analysis revealed that the I O and I D allele showed an increasing trend from the north to the center, while the I A and I d allele tended to increase from the center to the north. Also, we found more gene diversity in both loci in the north compared with the center, suggesting population structure in Mexico. This work could help health institutions to identify where they can obtain blood products necessary for medical interventions. Moreover, this piece of information contributes to the knowledge of the genetic structure of the Mexican populations which could have significant impl...Continue Reading

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Citations

Sep 18, 2020·Environmental Science and Pollution Research International·Diana Marcela Paredes-CéspedesYael Yvette Bernal-Hernández
Oct 6, 2020·Journal of Clinical Apheresis·Eduardo Cienfuegos-PecinaErik A Díaz-Chuc
Jul 20, 2021·Endocrinology, Diabetes & Metabolism·Carlos Martínez-MurilloJuan Francisco Zazueta
Oct 9, 2021·Scientific Reports·Adriana Martinez-CuazitlMonica M Mata-Miranda
Dec 9, 2021·The Journal of International Medical Research·Azar Dokht KhosraviAsma Abbasinezhad Poor

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Methods Mentioned

BETA
PCA

Software Mentioned

Minitab
POPTREEW

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