Blood groups, immunoglobulin allotypes and dermatoglyphic features of patients with amyotrophic lateral sclerosis and parkinsonism-dementia of Guam

American Journal of Medical Genetics
R M GarrutoD C Gajdusek

Abstract

Blood group frequencies, immunoglobulin allotypes, and dermatoglyphic patterns were determined on patients with amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD), two chronic, degenerative, neurologic disorders of unknown cause found commonly among the Chamorros of the Mariana Islands, in an attempt to identify a specific genetic or phenetic marker associated with either disorder. With the exception of the Kidd system, no significant differences were found in blood group frequencies nor in immunoglobulin allotypes between ALS patients, PD patients, and unaffected controls. The dermatoglyphic analysis demonstrated that ALS patients had higher frequencies of palmar patterns and accessory triradii in the IV interdigital area, and PD patients had significantly higher frequencies of complete simian creases and of palmar patterns in the thenar/I interdigital area than unaffected controls. The frequencies of the remaining dermatoglyphic traits showed no significant differences. We conclude that none of the marker systems tested show a particular pattern of association in patients and controls or a genetic predisposition to either disorder, and that early identification of at-risk individuals remains elusive.

References

Jan 1, 1983·Human Heredity·C C PlatoD C Gajdusek
Dec 1, 1980·Annals of Neurology·R M GarrutoK M Chen

Citations

Mar 1, 1975·American Journal of Physical Anthropology·C C PlatoD C Gajdusek
Oct 1, 1990·American Journal of Physical Anthropology·C Singh, K B McKnight
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R M GarrutoC E Fiori
Mar 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·N Fröhlander, L Forsgren
Jul 28, 2013·International Journal of Molecular Sciences·Francesca TrojsiGioacchino Tedeschi
Jul 1, 1986·Journal of Neurogenetics·H J Weinreb
Jan 1, 1989·American Journal of Human Biology : the Official Journal of the Human Biology Council·R M Garruto

Related Concepts

Amyotrophic Lateral Sclerosis, Guam Form
Blood Grouping and Crossmatching
Blood Group Antigens
Senile Paranoid Dementia
Plantar Prints
Genetic Markers
Polyglobin
Immunoglobulin Allotypes
Parkinson Disease

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