Blood Leukocyte Concentrations, FEV1 Decline, and Airflow Limitation. A 15-Year Longitudinal Study of World Trade Center-exposed Firefighters

Annals of the American Thoracic Society
Rachel Zeig-OwensMichael D Weiden

Abstract

Rescue/recovery work at the World Trade Center disaster site (WTC) caused a proximate decline in lung function in Fire Department of the City of New York firefighters. A subset of this cohort experienced an accelerated rate of lung function decline over 15 years of post-September 11, 2001 (9/11) follow-up. To determine if early postexposure blood leukocyte concentrations are biomarkers for subsequent FEV1 decline and incident airflow limitation. Individual rates of forced expiratory volume in 1 second (FEV1) change were calculated for 9,434 firefighters using 88,709 spirometric measurements taken between September 11, 2001, and September 10, 2016. We categorized FEV1 change rates into three trajectories: accelerated FEV1 decline (FEV1 loss >64 ml/yr), expected FEV1 decline (FEV1 loss between 0 and 64 ml/yr), and improved FEV1 (positive rate of change >0 ml/yr). Occurrence of FEV1/FVC less than 0.70 after 9/11 defined incident airflow limitation. Using regression models, we assessed associations of post-9/11 blood eosinophil and neutrophil concentrations with subsequent FEV1 decline and airflow limitation, adjusted for age, race, smoking, height, WTC exposure level, weight change, and baseline lung function. Accelerated FEV1 dec...Continue Reading

References

Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Nov 9, 2004·Environmental Health Perspectives·Elizabeth M FiremanDavid J Prezant
Jan 13, 2009·American Journal of Respiratory and Critical Care Medicine·Andrea BaccarelliJoel Schwartz
Apr 9, 2010·The New England Journal of Medicine·Thomas K AldrichDavid J Prezant
Sep 17, 2010·The New England Journal of Medicine·John R HurstUNKNOWN Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators
Jun 18, 2011·American Journal of Respiratory and Critical Care Medicine·Mona BafadhelChristopher E Brightling
Nov 19, 2011·American Journal of Respiratory and Critical Care Medicine·Bushra NaveedAnna Nolan
Dec 12, 2012·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Angeliki KazerosJoan Reibman
Dec 5, 2013·American Journal of Respiratory Cell and Molecular Biology·Emily A VucicWan L Lam
Mar 14, 2014·The Lancet. Respiratory Medicine·Michael H ChoUNKNOWN NETT Genetics, ICGN, ECLIPSE and COPDGene Investigators
Dec 8, 2015·American Journal of Respiratory and Critical Care Medicine·Signe Vedel-KroghBørge G Nordestgaard
Apr 21, 2016·Annals of the American Thoracic Society·Sophia KwonMichael D Weiden
Apr 24, 2016·Journal of the American Heart Association·Hyang-Min ByunAndrea A Baccarelli
Sep 11, 2016·The Journal of Allergy and Clinical Immunology·Diana A van der PlaatH Marike Boezen
Jun 12, 2017·The Lancet. Respiratory Medicine·Mona BafadhelRichard E K Russell

❮ Previous
Next ❯

Citations

Feb 2, 2018·Annals of the American Thoracic Society·George R Washko
Apr 9, 2019·American Journal of Respiratory and Critical Care Medicine·Wassim W LabakiSurya P Bhatt
Sep 3, 2020·International Journal of Environmental Research and Public Health·Hilary L ColbethDavid J Prezant
May 1, 2019·International Journal of Environmental Research and Public Health·Sophia KwonAnna Nolan
May 16, 2019·International Journal of Environmental Research and Public Health·Charles LiuMichael D Weiden
Apr 24, 2019·International Journal of Environmental Research and Public Health·Deepak PradhanKenneth I Berger
Feb 19, 2020·Annals of the American Thoracic Society·Barbara PutmanMichael D Weiden
Nov 28, 2020·The Clinical Respiratory Journal·Xiaoyu LiuRafael E de la Hoz
Dec 10, 2020·International Journal of Environmental Research and Public Health·Barbara PutmanMichael D Weiden
Jul 22, 2021·PLoS Computational Biology·George CrowleyAnna Nolan
Jul 22, 2021·American Journal of Industrial Medicine·Michael D WeidenDavid J Prezant

❮ Previous
Next ❯

Software Mentioned

Prism
GraphPad

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.