Blood level of tacrolimus in patients with severe allergic conjunctivitis treated by 0.1% tacrolimus ophthalmic suspension

Allergology International : Official Journal of the Japanese Society of Allergology
Nobuyuki EbiharaDai Miyazaki

Abstract

To estimate the efficacy and safety of 0.1% tacrolimus ophthalmic suspension based on the blood level of tacrolimus in patients with severe allergic conjunctivitis. Fifty-two patients in whom topical anti-allergic agents had been ineffective were treated with 0.1% tacrolimus ophthalmic suspension twice daily for 12 weeks. Adverse drug reactions were monitored, as well as ocular symptoms and signs. The blood concentration of tacrolimus was measured before the initiation of treatment and 4 and 12 weeks later. About 75% of the patients without concomitant using of tacrolimus ointment had blood levels of tacrolimus below the detection limit of the assay (0.5ng/mL). On the other hand, 71% (week 4) and 57% (week 12) of patients with concomitant using of tacrolimus ointment had blood levels above the detection limit of the assay. However, the maximum blood concentration was less than 2ng/mL. Adverse drug reactions occurred in 16 patients. These were disorders of the eye such as warmness, irritation, and a burning sensation. However, all of the patients could continue treatment with tacrolimus for 12 weeks. There were no serious adverse events such as increased intraocular pressure or ocular infection during the study. All symptoms and...Continue Reading

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Citations

Apr 4, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Eliya LevingerDavid Verssano
Feb 26, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Neri PucciElio Novembre
Jul 3, 2015·American Journal of Ophthalmology·Maria Carolina MarquezanDenise Freitas
Jul 18, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Hirohisa Saito, Toshio Heike
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Apr 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Leslie RebiboSimon Benita
Aug 10, 2021·American Journal of Ophthalmology Case Reports·Jacob MartinDeborah Costakos

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