Blood levels of histamine, IL-1 beta, and TNF-alpha in patients with mild to moderate Alzheimer disease

Molecular and Chemical Neuropathology
X A AlvarezRamón Cacabelos

Abstract

In this study, we have evaluated the levels of blood histamine, serum interleukin-1 beta (IL-1 beta), and plasma tumor necrosis factor-alpha (TNF-alpha) in 20 patients with mild to moderate Alzheimer disease (AD; 13 early onset and 7 late-onset AD subjects) and in 20 age-matched control subjects (C). AD patients showed higher concentrations of histamine (AD = 452.9 +/- 237.9 pmol/mL; C = 275.3 +/- 151.5 pmol/mL; p < 0.05) and IL-1 beta (AD = 211.2 +/- 31.1 pg/mL; C = 183.4 +/- 24.4 pg/mL; p < 0.01), and lower values of TNF-alpha (AD = 3.59 +/- 2.02 pg/mL; C = 9.47 +/- 2.64 pg/mL; p < 0.001) than elderly controls. Increased levels of histamine and decreased levels of TNF-alpha were observed in both early onset AD (EOAD) and late-onset AD (LOAD) patients, but only EOAD subjects had elevated serum IL-1 beta values compared with age-matched controls. Age negatively correlated with histamine (r = -0.57; p < 0.05) and positively with IL-1 beta levels (r = 0.48; p < 0.05) in healthy subjects, but not in AD, whereas a positive correlation between TNF-alpha scores and age was only found in AD patients (r = 0.46; p < 0.05). Furthermore, histamine and TNF-alpha values correlated negatively in AD (r = -0.50, p < 0.05). In addition, cogniti...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Nov 1, 1992·Neurobiology of Aging·D W Dickson, J Rogers
Aug 19, 1991·Neuroscience Letters·H FillitG Wolf-Klein
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·L D Altstiel, K Sperber
Jan 1, 1991·International Archives of Allergy and Applied Immunology·G HotermansM F Radermecker
Jul 1, 1991·The Journal of Experimental Medicine·E VannierC A Dinarello
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·A R Hermus, C G Sweep
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D GoldgaberD C Gajdusek
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W S GriffinC Araoz
Jan 1, 1989·Canadian Journal of Physiology and Pharmacology·I M Mazurkiewicz-Kwilecki, S Nsonwah
Jan 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L Fernández-NovoaR Cacabelos
Sep 24, 1993·Annals of the New York Academy of Sciences·R CacabelosJ Caamaño
Jan 1, 1993·Glia·P L McGeerE G McGeer
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·N J Rothwell, J K Relton
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

❮ Previous
Next ❯

Citations

Sep 5, 2002·Annals of Neurology·Reinhold SchmidtLenore J Launer
Apr 3, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ulrike Träger, Sarah J Tabrizi
Jun 20, 2006·European Archives of Psychiatry and Clinical Neuroscience·Chie YasutakeHiroshi Yoneda
May 8, 2004·Experimental Gerontology·Karen Suárez KrabbeHelle Bruunsgaard
May 24, 2005·Journal of Neuroimmunology·Pankaj D MehtaPatricia K Coyle
Apr 26, 2003·Mechanisms of Ageing and Development·Federico Licastro, Martina Chiappelli
Oct 20, 2001·Behavioural Brain Research·L Fernández-Novoa, R Cacabelos
Jan 1, 2011·Translational Psychiatry·M OrešičH Soininen
Apr 27, 2000·Proceedings of the Society for Experimental Biology and Medicine·B R LackeyD M Henricks
Dec 11, 2002·Journal of the American Geriatrics Society·Craig J WilsonHarvey J Cohen
Aug 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tapan K Khan, Daniel L Alkon
Mar 8, 2002·Alzheimer Disease and Associated Disorders·Michelle C CarlsonJohn C S Breitner
Dec 14, 2011·PloS One·Jan-Sebastian GrigoleitManfred Schedlowski
Sep 29, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Maartje I KesterCees B Oudejans
Mar 16, 2016·Neural Plasticity·Vanja DuricLi-Lian Yuan
Mar 30, 2006·Neurobiology of Aging·Antón AlvarezManuel Aleixandre
May 18, 2016·Mediators of Inflammation·Ramón CacabelosFrancisco López-Muñoz
Jul 5, 2013·The International Journal of Neuroscience·Aidonio FiolakiSotirios Giannopoulos
Jul 8, 2014·Frontiers in Cellular Neuroscience·Cristy PhillipsAhmad Salehi
Jun 5, 2016·Journal of Neuroinflammation·Sandra M RochaLiliana Bernardino
Jul 8, 2010·Journal of Neuroimmunology·Anjali Pandey, Sarang Bani
Sep 28, 2016·BMC Neurology·Raphael HesseChristine A F von Arnim
Mar 13, 2017·Journal of Neuroinflammation·Rebecca MontacuteStuart McRae Allan
Feb 28, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Yanan ZhuMitchell K P Lai
Dec 12, 2012·American Journal of Alzheimer's Disease and Other Dementias·Ching-Wen HuangIrene H Cheng
Mar 16, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Kaavya NarasimhaluChristopher Chen
Dec 31, 2011·World Journal of Psychiatry·Christian Humpel, Tanja Hochstrasser
Feb 26, 2014·Molecular Neurobiology·Frederic BrosseronMichael T Heneka
Dec 19, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Eleanor KingAlan J Thomas
Nov 30, 2006·Psychosomatic Medicine·Anna L MarslandStephen B Manuck
Jun 6, 2017·Aging and Disease·Anindita BanerjeeSasanka Chakrabarti
Oct 16, 2007·Neuro-degenerative Diseases·Rita João GuerreiroCatarina Oliveira
Aug 16, 2012·Stem Cells·Liliana BernardinoJoão O Malva
Oct 11, 2012·Neuropathology and Applied Neurobiology·C Holmes
Nov 28, 2002·Annals of Medicine·Ramón Cacabelos
Apr 25, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yichayaou BelooseskyVivian Barak

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