PMID: 3489354Jan 1, 1986Paper

Blood lymphocyte subsets in patients with primary intracranial tumours. Correlation to histological tumour type and anatomical site

Acta neurochirurgica
H UllénH von Holst

Abstract

The blood lymphocyte population of 118 patients with primary intracranial tumours and healthy volunteers was examined with respect to its size and cellular composition using various rosette tests. The patients had not undergone any surgical intervention or received any treatment with ionizing irradiation or cytotoxic drugs. However, some of them were treated with corticosteroids. It was observed that non-steroid treated patients with oligodendrogliomas, but not patients with other histological types of tumours, had a significantly reduced proportion of "active" T-lymphocytes forming rosettes with sheep erythrocytes (a type of T-lymphocyte which is activated by foetal calf serum). These patients as well as those with astrocytomas, malignant gliomas (anaplastic astrocytomas and glioblastomas) or miscellaneous tumours (mainly meningiomas) had normal proportions of lymphocytes with receptors for the Fc-part of IgG or C'3 and cells forming rosettes with sheep erythrocytes under more conventional conditions. Patients who were treated with corticosteroids had an increased frequency of lymphocytes with the above Fc-receptor. An association between site of the lesions and cellular composition of the blood lymphocyte population was not d...Continue Reading

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Citations

May 1, 1989·Journal of Neurosurgery·J VaqueroF G Salazar
Aug 1, 1992·Journal of Neurosurgery·J SchneiderD R Hinton
Feb 19, 2013·Immunotherapy·Christopher JacksonMichael Lim
Dec 1, 1989·Journal of Neuroimmunology·C de Micco
Jan 1, 1990·Acta neurochirurgica·J VaqueroR Martínez
Oct 2, 2003·British Journal of Cancer·A Talvensaari-MattilaT Turpeenniemi-Hujanen
Sep 1, 1990·Clinical Cardiology·T KandaK Murata
Aug 29, 2014·Journal of Neuro-oncology·Eli T SayeghAndrew T Parsa

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