Abstract
Recent studies have failed to show reductions in rates of red blood cell (RBC) transfusion after total joint arthroplasty (TJA) in the United States. This study aims to report the 19-year trend analysis of blood use in TJA, to determine predictors of RBC transfusion and association between RBC transfusion and in-hospital mortality after TJA using a nationally representative database. Nationwide inpatient sample (NIS) data from 1993 to 2011 were used. ICD-9-CM codes were used to identify TJA cases, RBC transfusion, autologous blood transfusion, and/or transfusion from cell salvage. Logistic regression analysis was performed to determine predictors of RBC transfusion and if transfusion increases risk of in-hospital mortality. A total of 2,225,054 TJA cases were identified. Using multivariate analysis, there was an increase in the rate of RBC transfusion over the study period (odds ratio [OR], 1.049; 95% confidence interval [CI], 1.048-1.050; p < 0.001). One-stage bilateral TJA (OR, 3.30; 95% CI, 3.24-3.37; p < 0.001), anemia due to chronic blood loss (OR, 2.69; 95% CI, 2.59-2.74, p < 0.001), deficiency anemia (OR, 2.59; 95% CI, 2.56-2.62; p < 0.001), and Charlson comorbidity index (OR, 1.24; 95% CI, 1.23-1.24; p < 0.001) were ind...Continue Reading
References
Jan 1, 1987·Journal of Chronic Diseases·M E CharlsonC R MacKenzie
Feb 11, 1999·The Journal of Bone and Joint Surgery. American Volume·B E BierbaumR B Welch
Feb 28, 2002·The Journal of Bone and Joint Surgery. American Volume·Jose A SalidoCristóbal Martínez
Mar 29, 2003·Transfusion·Nadia RosencherUNKNOWN OSTHEO Investigation
Nov 19, 2003·Acta Orthopaedica Scandinavica·Robert SlappendelDick B van der Schaaf
Dec 9, 2004·Transfusion·Jonathan H Waters
Oct 15, 2005·Medical Care·Hude QuanWilliam A Ghali
Feb 27, 2007·Transfusion·Adrianus F C M MoonenPeter Pilot
Nov 14, 2007·Circulation·Gavin J MurphyGianni D Angelini
Mar 12, 2008·Expert Review of Medical Devices·German A MarulandaMichael A Mont
Apr 2, 2008·The Journal of Bone and Joint Surgery. British Volume·A AminM Loeffler
Apr 19, 2008·Clinical Orthopaedics and Related Research·Luis PulidoJavad Parvizi
Aug 2, 2008·The Journal of Bone and Joint Surgery. British Volume·A F C M MoonenP Pilot
Dec 17, 2008·The Journal of Trauma·Milo EngorenJoseph Sferra
May 19, 2009·Anesthesia and Analgesia·Stephen D SurgenorUNKNOWN Northern New England Cardiovascular Disease Study Group
Jul 9, 2010·Anesthesiology·Donat R Spahn
Jan 5, 2011·The Journal of Bone and Joint Surgery. British Volume·M SukeikJ M Mason
Jan 18, 2011·Anesthesiology·Laurent G GlanceTurner M Osler
May 31, 2011·The Journal of Knee Surgery·Javad ParviziRichard H Rothman
Oct 12, 2011·Transfusion·Jonathan H WatersMark H Yazer
Dec 14, 2011·The Journal of Bone and Joint Surgery. British Volume·S AlshrydaJ M Mason
Dec 16, 2011·The New England Journal of Medicine·Jeffrey L CarsonUNKNOWN FOCUS Investigators
Feb 22, 2012·Transfusion·Vidya K RaoJonathan H Waters
Mar 9, 2012·Lancet·Andrew J CarrDavid J Beard
Apr 24, 2012·Vox Sanguinis·Ø JansP I Johansson
Jul 4, 2012·Annals of Internal Medicine·Jeffrey L CarsonUNKNOWN Clinical Transfusion Medicine Committee of the AABB
Oct 2, 2012·Lancet·Robert PivecMichael A Mont
Mar 27, 2013·The Journal of Arthroplasty·Khalid AlsalehC Tom Kouroukis
Apr 25, 2013·Anesthesiology·Stavros G MemtsoudisNigel E Sharrock
May 15, 2013·The Journal of Arthroplasty·Mohammad R RasouliJavad Parvizi
Jul 9, 2013·Transfusion·Øivind JansUNKNOWN Lundbeck Foundation Centre for Fast-track Hip and Knee Replacement Collaborative Group
Jul 31, 2013·The Journal of Arthroplasty·James A BrowneWendy M Novicoff
Oct 4, 2013·The Journal of Bone and Joint Surgery. American Volume·Jai Hyung ParkJavad Parvizi
Oct 15, 2013·The Journal of Knee Surgery·Samik BanerjeeMichael A Mont
Nov 21, 2013·Spine·Hiroyuki Yoshihara, Daisuke Yoneoka
Dec 7, 2013·International Orthopaedics·Sanja Jakovina BlazekovicDomagoj Delimar
Dec 24, 2013·The Journal of Arthroplasty·Mohammad R RasouliJonathan H Waters
Jan 15, 2014·The Journal of Arthroplasty·Max GreenkyWilliam J Hozack
Jan 28, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mohammad R RasouliJonathan H Waters
Mar 4, 2014·TheScientificWorldJournal·Thomas DanningerStavros G Memtsoudis
Jun 4, 2014·The Journal of Arthroplasty·Hiroyuki Yoshihara, Daisuke Yoneoka
Jun 4, 2014·The Journal of Arthroplasty·Hiroyuki Yoshihara, Daisuke Yoneoka
Feb 13, 2015·Journal of Shoulder and Elbow Surgery·Devon J RyanJoseph D Zuckerman
Citations
Mar 16, 2018·Transfusion·Michael A MazzeffiKenichi Tanaka
Jan 22, 2017·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Ankit KansagraMihaela S Stefan
Jul 11, 2018·Anaesthesia·A A KleinF Torella
Dec 9, 2017·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Chukwuweike U GwamRonald E Delanois
Nov 16, 2018·Journal of Thrombosis and Haemostasis : JTH·D WangW-N Zeng
Mar 8, 2019·The Journal of Bone and Joint Surgery. American Volume·Duan WangWei-Nan Zeng
Apr 3, 2019·Journal of Orthopaedic Trauma·Clay A SpitlerDirk W Kiner
Jan 31, 2019·BMJ Open·Qi SunYusong Jia
Jun 20, 2020·The Journal of Bone and Joint Surgery. American Volume·Antony J R PalmerGeorge Grammatopoulos
Nov 3, 2017·The Bone & Joint Journal·J XieF Pei
Nov 23, 2019·Stem Cell Research & Therapy·Katharina HenzeMarcus Jäger
Aug 24, 2017·BMC Musculoskeletal Disorders·Syed Hamza MufarrihShahryar Noordin
Oct 6, 2020·Transfusion·Michael MazzeffiKenichi Tanaka
Apr 14, 2020·Annals of Surgery·Wan Yi TeohChew Yin Wang
Jun 22, 2021·Clinical Hemorheology and Microcirculation·Chen XuJianzhong Guan
Oct 30, 2021·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·SaTia T SinclairNicolas S Piuzzi
Apr 25, 2019·The Journal of Thoracic and Cardiovascular Surgery·Dhaval KolteAfshin Ehsan