PMID: 7538057May 1, 1995Paper

Blood monocytes of untreated asthmatics exhibit some features of tissue macrophages

Clinical and Experimental Immunology
A RivierA M Campbell

Abstract

Airway macrophages are activated in asthmatic subjects. Peripheral blood monocytes from these subjects present some functional features of activation, but their membrane markers are not known. Recently a new subtype of blood monocytes, CD14+/CD16+, has been identified which possesses the characteristics of tissue macrophages. A study was carried out on nine normal subjects and 11 untreated asthmatics having variable severities of the disease to examine the phenotypic characteristics of monocytes. CD14, CD16, HLA-DR, CD11a, CD11b, CD44 and CD54 were studied using double fluorescence flow cytometry since these antigens have been defined in the CD14+/CD16+ monocytes. The functional activation of monocytes was examined using the release of superoxide anion. The co-expression of CD14 and CD16 by monocytes in terms of percentage and mean fluorescence intensity was significantly higher in asthmatics (P < 0.002 and P < 0.0001, respectively, Mann-Whitney U-test). There was no difference for the other membrane markers between asthmatics and normal subjects. Superoxide anion release was significantly increased in asthmatic subjects (P < 0.01). This study shows that most blood monocytes of asthmatics are CD14+/CD16+ and are likely to prese...Continue Reading

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Citations

Feb 13, 2001·Clinical and Experimental Immunology·W A NockherJ E Scherberich
Aug 21, 2003·The Journal of Dermatology·Hiroyuki OkamotoTakeshi Horio
Dec 1, 2006·Journal of Leukocyte Biology·Loems Ziegler-Heitbrock
Feb 18, 2009·Clinical and Experimental Immunology·P AmoudruzE Sverremark-Ekström
Apr 26, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Baoying LiuRobert B Nussenblatt
Apr 29, 2009·Expert Opinion on Therapeutic Targets·Martin D Knolle, Caroline A Owen
Jan 21, 2012·Scandinavian Journal of Immunology·K KowalA Bodzenta-Lukaszyk
Jan 15, 2014·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Jean-Claude LaprazPatrice Pauly
Nov 17, 2019·Genes·Andrée-Anne Hudon Thibeault, Catherine Laprise
Jan 19, 2008·Scandinavian Journal of Immunology·J Skrzeczyńska-MoncznikJ Pryjma
Oct 18, 2002·Arthritis and Rheumatism·Norikuni KawanakaHirofumi Makino
Aug 26, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Lakshitha P GunawardhanaKatherine J Baines
Aug 22, 2006·Immunobiology·Thomas P J HoferLöms Ziegler-Heitbrock

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