Blood natural killer cells during treatment in recurrent ovarian cancer

Acta Oncologica
Jon Røikjær HenriksenKarina Dahl Steffensen

Abstract

Recent research indicated favorable prognostic impact of intratumoral natural killer (NK) cells in ovarian carcinoma (OC). The role of NK cells during chemotherapy in OC is unknown. We investigated impact of NK cells in OC patients treated with palliative chemotherapy. Participants receiving palliative chemotherapy for recurrent OC (N = 72) had prospectively blood samples at baseline and before cycle 2. NK cell counts were quantified by flow cytometry. NK cell activity was measured by the NK Vue® assay, estimating interferon-gamma production. Overall survival (OS) was the primary endpoint. Cutoffs were predefined, NK numbers (≥184 × 106 cells/L vs. <184 × 106 cells/L) and NK activity (<200 pg/mL vs. ≥200 pg/mL). Median OS in patients with low vs. high NK cell count at baseline was 7.1 months vs. 15.6 months (p = .028), respectively, and before cycle 2 was 5.7 vs. 17.3 months, p < .001, respectively. The difference in restricted mean survival (ΔRMST) was 5.7 months (95% CI: 3.3-8.0) at cycle 2 vs. 2.5 months (95% CI: -0.6 to 5.6) at baseline, showing a significant difference with no overlap of confidence intervals. In multivariate analyses, low NK cell count remained significant with a hazard ratio (HR)=2.83, 95% CI: 1.53-5.22, ...Continue Reading

References

Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·Y KikuchiI Nagata
Oct 1, 1989·Clinical Immunology and Immunopathology·T L Whiteside, R B Herberman
Oct 1, 1995·Current Opinion in Immunology·T L Whiteside, R B Herberman
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan K LutgendorfDavid M Lubaroff
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Kelly Marie RedmondDaniel Broderick Longley
Mar 13, 2009·Immunology·Aurélie PoliJacques Zimmer
Nov 13, 2010·Blood·Lorenzo Moretta
Jan 8, 2011·Science·Eric VivierSophie Ugolini
Jan 29, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Gordon John Sampson RustinUNKNOWN Gynecological Cancer Intergroup
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Apr 2, 2011·Journal of Innate Immunity·Yenan T BrycesonStephanie M Wood
Aug 23, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L C HankerUNKNOWN AGO and GINECO study group
Feb 25, 2014·Biochemical and Biophysical Research Communications·Saet-byul LeeJongsun Kim
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Mar 31, 2015·Seminars in Cancer Biology·Dass S VinayByoung S Kwon
Sep 11, 2017·Seminars in Immunology·Karl-Johan MalmbergHans-Gustaf Ljunggren
Oct 22, 2017·Journal of Gastroenterology and Hepatology·Yoon Suk JungJung Ho Park
Dec 23, 2017·Current Oncology·J FrancisUNKNOWN Gynecologic Cancer Disease Site Group
Apr 15, 2018·Journal of Immunological Methods·Line NederbyTorben Frostrup Hansen
Mar 16, 2019·Scientific Reports·Kaat de JongeDaniel E Speiser
May 3, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U A MatulonisJ A Ledermann
May 6, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Magdalena KlanovaGünter Fingerle-Rowson
May 20, 2019·Translational Oncology·Torben Frøstrup HansenAnders Jakobsen
Aug 29, 2019·Frontiers in Immunology·Sarah NersesianJeanette E Boudreau
Jan 15, 2020·Acta Oncologica·Jon Røikjaer HenriksenKarina Dahl Steffensen
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U A MatulonisJ A Ledermann
Jul 22, 2020·Acta Oncologica·Jon Røikjær HenriksenKarina Dahl Steffensen

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Jul 22, 2020·Acta Oncologica·Jon Røikjær HenriksenKarina Dahl Steffensen

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