Blood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from Tuberculosis in Children

BioMed Research International
Linda PetroneDelia Goletti

Abstract

Interferon-γ inducible protein 10 (IP-10), either in blood or in urine, has been proposed as a tuberculosis (TB) biomarker for adults. This study aims to evaluate the potential of IP-10 diagnostics in children from Uganda, a high TB-endemic country. IP-10 was measured in the blood and urine concomitantly taken from children who were prospectively enrolled with suspected active TB, with or without HIV infection. Clinical/microbiological parameters and commercially available TB-immune assays (tuberculin skin test (TST) and QuantiFERON TB-Gold In-Tube (QFT-IT)) were concomitantly evaluated. One hundred twenty-eight children were prospectively enrolled. The analysis was performed on 111 children: 80 (72%) of them were HIV-uninfected and 31 (27.9%) were HIV-infected. Thirty-three healthy adult donors (HAD) were included as controls. The data showed that IP-10 is detectable in the urine and blood of children with active TB, independent of HIV status and age. However, although IP-10 levels were higher in active TB children compared to HAD, the accuracy of identifying "active TB" was low and similar to the TST and QFT-IT. IP-10 levels are higher in children with respiratory illness compared to controls, independent of "TB status" sugge...Continue Reading

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Citations

Oct 30, 2016·Journal of Clinical Laboratory Analysis·Ahmed El-GoharySamah Ismail Nasef
Nov 18, 2015·PLoS Neglected Tropical Diseases·Linda PetroneDelia Goletti
Feb 20, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Delia GolettiTom H M Ottenhoff
Nov 28, 2017·Biomarkers in Medicine·Laneke LuiesDu Toit Loots
Oct 27, 2018·The European Respiratory Journal·Delia GolettiFrank Cobelens
Nov 2, 2019·BMC Infectious Diseases·Xia QiuDezhi Mu
Oct 18, 2016·The Pediatric Infectious Disease Journal·Roberta PetrucciPaola Dal Monte
Aug 11, 2017·BMC Infectious Diseases·Anne F M JansenMarcel van Deuren
Sep 20, 2020·BMC Pulmonary Medicine·Zhenhong WeiXiaoling Gao
Sep 16, 2021·The Pediatric Infectious Disease Journal·Christine AnterasianThomas R Hawn

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Methods Mentioned

BETA
bronchoalveolar
lavage
biopsies

Software Mentioned

SPSS
Prism

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