Blood Orange Juice Consumption Increases Flow-Mediated Dilation in Adults with Overweight and Obesity: A Randomized Controlled Trial

The Journal of Nutrition
Lu LiChristine Boesch

Abstract

Epidemiological studies have indicated an inverse association between citrus fruit consumption and cardiovascular disease (CVD) risk. There is, however, a paucity of data concerning effects of blood orange juice (BOJ) intake on endothelial function and cardiovascular risk biomarkers. We examined short-term effects of BOJ on endothelial function, blood pressure, lipid profile, and inflammatory markers in healthy participants of European origin who were overweight or obese. In a randomized, controlled, single-blind, crossover trial, 15 men and women (age: 28.7 ± 6.5 y; BMI: 28.3 ± 3.1 kg/m2) consumed BOJ or a sugar-matched control drink (CD) (200 mL twice daily) for 2 wk with a washout period of 1 wk. Endothelial function, measured as flow-mediated dilation (FMD) (primary outcome), and the secondary outcomes blood pressure, anthropometric measures, lipid profile, inflammatory markers, markers of vasodilation and vasoconstriction, and urinary flavanone metabolites were evaluated prior to and at the end of each treatment period following an overnight fast. Changes between treatments over time were assessed using repeated-measures ANOVA. The results demonstrate a significant increase in FMD following BOJ consumption (pre: 8.15% ± 2....Continue Reading

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Citations

Mar 9, 2021·Frontiers in Neuroscience·Matthew G PontifexDavid Vauzour
May 21, 2021·Critical Reviews in Food Science and Nutrition·Farah J Tadros, Jeanette Mary Andrade
Jun 3, 2021·Biomolecules·Ioana MozosAtanas G Atanasov
Jun 3, 2021·Nutrients·Carrie H S Ruxton, Madeleine Myers
Aug 7, 2021·Pharmaceuticals·Ana C GonçalvesLuís R Silva

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