PMID: 240284Aug 1, 1975

Blood oxygen affinity and alveolar ventilation in relation in body weight in mammals

The American Journal of Physiology
S Lahiri

Abstract

The validity of the concept relating blood oxygen affinity and alveolar ventilation to body weight in homeothermic mammals was reexamined with blood pH used as the fixed variable. Blood Po2 at 50% saturation at pH 7.4 (P50(7.4)) and PCO2 of oxygenated blood at pH 7.4 (PCO2(7.4)) from a variety of homeothermic mammals were determined at 37 degrees C by in vitro equilibration techniques. In some species, arterial PCO2, PO2, and pH were also measured. PCO2(7.4), which was similar to arterial PCO2, showed a correlation coefficient of +0.33 with body weight over the range of 28-100,000 g and +0.90 among the species under 200 g. P50(7.4) values, which ranged from 26.0 to 38.7 mmHg for all the species, were not well correlated (r = -0.43) with body weight. For the small mammals (less than 200 g) the correlation coefficient was -0.91. In vivo P50 at the body temperature and arterial pH, although different from P50(7.4), showed a similar correlation with body weight. The lack of valid generalization suggests that body weight is only one of the composite factors that influence O2 transport systems.

Citations

Jun 12, 1979·Pflügers Archiv : European journal of physiology·M Stupfel, D Costagliola
Jul 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T DalkaraM A Moskowitz
Apr 1, 1993·Clinical and Experimental Pharmacology & Physiology·U QuatriniG Morici
Nov 19, 2017·The Journal of Experimental Biology·Stanley S Hillman, Michael S Hedrick
Oct 1, 1996·Journal of Applied Physiology·J C LaMannaN S Cherniack
May 1, 1987·Pflügers Archiv : European journal of physiology·H Kiwull-SchöneP Kiwull
Sep 3, 2016·Journal of Applied Physiology·Edward P SnellingShane K Maloney
Feb 5, 2005·Journal of Applied Physiology·James H Stuhmiller, Louise M Stuhmiller
Apr 10, 2008·Biological Reviews of the Cambridge Philosophical Society·Göran E Nilsson, Sara Ostlund-Nilsson
Oct 15, 1979·Experientia·L Gattinoni, M Samaja
Aug 25, 1978·Pflügers Archiv : European journal of physiology·Z TurekB E Ringnalda
Feb 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·F ArévaloP López-Luna

Related Concepts

Blood Gas Analysis
Carbon Dioxide
Felis catus
Canis familiaris
Psammomys
Goat
Cavia porcellus
Cricetus
Hydrogen-Ion Concentration
Didelphidae

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.