Blood oxygen binding in calves with naturally occurring diarrhea

American Journal of Veterinary Research
C CambieP Gustin

Abstract

To assess blood oxygen binding in calves with diarrhea. 22 dairy and 26 double-muscled calves with diarrhea, 31 healthy dairy calves and 37 healthy double-muscled calves. Severity of disease, including the ability of affected calves to stand, was evaluated. Hydration and signs of depression were scored. Venous and arterial blood samples were collected, and 2,3-diphosphoglycerate, ATP, chloride, inorganic phosphate, lactate, pyruvate, total protein, albumin, and hemoglobin concentrations, and Hct, pH, Pco2, and PO2 were determined. Oxygen equilibrium curves (OEC) were constructed under standard conditions, and oxygen extraction ratios were calculated. Recumbent calves of both breed-types were more dehydrated and had more severe signs of depression than ambulatory affected calves. In both breed-types, hemoglobin oxygen affinity was increased in calves with diarrhea, compared with healthy calves, as indicated by a decrease in standard partial oxygen pressure (P50). Diarrhea induced hypocapnia and hypothermia in the most severely affected calves, which counteracted the acidosis-induced right shift in arterial and venous OEC. Arterial and venous P50 were significantly less in double-muscled calves with diarrhea than healthy calves, ...Continue Reading

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Citations

Apr 27, 2013·Research in Veterinary Science·Francisco Escalera-ValenteVicente R Gaudioso-Lacasa
Feb 27, 2007·The Veterinary Journal·C CambierP Gustin
Feb 25, 2005·The Veterinary Journal·C CambierP Gustin
Apr 3, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Michael A Posternak, Mark Zimmerman

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