Blood oxygen level-dependent magnetic resonance imaging of the human liver: preliminary results

Journal of Computer Assisted Tomography
Zhaoyang FanMichael D Noseworthy

Abstract

To investigate blood oxygen level-dependent (BOLD) response of human liver to hyperoxic exposure under fasting and postprandial conditions. Twelve healthy volunteers and 1 patient with chronic liver disease underwent liver BOLD magnetic resonance imaging at 3.0T. The BOLD images of a single slice were collected (1 image per second) during 3 breathing cycles of hyperoxia (3 minutes, 100% oxygen) with 5 minutes medical air (20.8% oxygen) in both preprandial and postprandial states. The BOLD signal time courses were correlated with a predefined stimulus paradigm. Eight healthy subjects showed increased BOLD signal within 44.6% +/- 21.1% liver area in the fasting state with gas cycling. Two showed slightly reduced BOLD signal within 23.4% +/- 14.9% liver area in the fasting state with gas cycling. In the postprandial state, the degree of change in BOLD signal with gas cycling was reduced for both the subjects having increased and those having decreased signal with gas cycling (13.4% +/- 12.6% positive, 10.9% +/- 10.1% negative; P < 0.05). Chronic liver disease also demonstrated increased BOLD signal with gas cycling, but the correlation decreased postprandially. The proposed physiological challenges induce certain BOLD signal respo...Continue Reading

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Citations

Jul 26, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jun XiaYi Lei
Jun 20, 2017·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Fang YuanChunchao Xia
May 11, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A SørensenN Uldbjerg
Sep 6, 2013·Journal of Magnetic Resonance Imaging : JMRI·Yifat EdreiRinat Abramovitch
Mar 2, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yi ZhangTimothy Q Duong

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