PMID: 9436941Jan 22, 1998Paper

Blood oxygenation level dependent signal time courses during prolonged visual stimulation

Magnetic Resonance Imaging
A HowsemanR Turner

Abstract

Previous functional magnetic resonance imaging (MRI) studies using extended visual stimulation have reported disparate results. Two studies have shown that blood oxygen level dependent (BOLD) contrast decays over time which is cited as evidence of recoupling between oxygen utilisation and cerebral blood flow during stimulus presentation. These findings have serious implications for the design of functional MRI experiments because they raise the possibility that BOLD contrast may not accurately reflect neuronal activity. Another study reported no decay of BOLD contrast. These studies used different visual stimuli and imaging techniques. We have performed a series of experiments, using different MRI techniques (echo-planar imaging and fast low angle shot) and two different visual stimuli to assess which of these factors may explain the previous results. In all of our experiments the signal time course from areas of significant activation remained largely elevated throughout the duration of stimulation and this is not affected by the imaging method used. Our data, in accordance with that of Bandettini et al., suggest that recoupling between blood flow and oxygen extraction is not a general phenomenon in the human brain when visual...Continue Reading

References

Sep 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·J FrahmW Hänicke
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K K KwongR Turner
Jun 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A BandettiniJ S Hyde
Jul 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D Sappey-MarinierM W Weiner
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S OgawaK Ugurbil
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J PrichardR Shulman
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P T Fox, M E Raichle
Jul 1, 1994·Journal of Magnetic Resonance Imaging : JMRI·G M HathoutR M Harper
Jan 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmW Hänicke
Feb 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmA Kleinschmidt
Jun 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G KrügerJ Frahm
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·F HyderR G Shulman
Jan 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R B Buxton, L R Frank

❮ Previous
Next ❯

Citations

Sep 3, 2002·Journal of Neuroscience Methods·Martin J McKeownGregory McCarthy
Feb 13, 2001·Brain Research. Cognitive Brain Research·J I TracyD Burkland
Oct 26, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A KastrupM E Moseley
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A M Howseman, R W Bowtell
Oct 9, 2009·Medical Physics·Michele ButtiAlessandro Torricelli
Jan 28, 2012·NeuroImage·Gunnar Krueger, Cristina Granziera
May 21, 1999·NeuroImage·R D HogeG B Pike
Nov 8, 2019·The Journal of Physiology·Till NierhausArno Villringer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
J FrahmA Kleinschmidt
Current Biology : CB
Dominik Straumann, Christopher J Bockisch
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
W ChenK Ugurbil
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
H R HeekerenA Villringer
© 2021 Meta ULC. All rights reserved