PMID: 18717114Aug 23, 2008Paper

Blood platelet count and severity of decompression sickness in rats after a provocative dive

Aviation, Space, and Environmental Medicine
Jean-Michel PontierNicolas Vallée

Abstract

Previous animal studies reported that platelet count (PC) is decreased following decompression. Adherence and aggregation of platelets to the bubble surface has been demonstrated in severe decompression sickness (DCS). The present study was designed to clarify the relationship between post-dive platelet levels and the severity of DCS in a rat model. A total of 57 male Sprague-Dawley rats were assigned to either one experimental group with a hyperbaric exposure (N = 22) or one control group (N = 27). Rats were compressed to 1000 kPa (90 msw) for 45 min while breathing air and decompressed to surface in 38 min with stops at 200, 160, and 130 kPa. Onset of neurological DCS and death time were recorded during a 120-min observation period after surfacing. In the control group, rats were maintained at atmospheric pressure in the same chamber for an equivalent period of time. Blood samples for PC were taken 30 min before and immediately after exposure in two groups. Blood PC after hyperbaric exposure had significantly decreased, whereas PC had increased in the control group. We found a correlation between % fall in PC and latency to death time. The platelet loss tended to decrease when fatal DCS was delayed. Rats suffering from severe...Continue Reading

Citations

Aug 21, 2013·European Journal of Applied Physiology·Kate LambrechtsFrançois Guerrero
Jun 28, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jean-Michel PontierMihaela Ignatescu
Jan 8, 2011·Journal of Applied Physiology·Jean-Michel PontierLionel Bourdon
Nov 19, 2010·Annals of Indian Academy of Neurology·Uday A PhatakPravin M Kulkarni
Mar 19, 2015·Respiratory Physiology & Neurobiology·Xiao-Chen BaoFang-Fang Wang
Apr 24, 2016·Journal of Thrombosis and Thrombolysis·Peter Buzzacott, Andreas Mollerlokken
Jan 23, 2017·European Journal of Applied Physiology·Kate LambrechtsFrançois Guerrero
Feb 9, 2016·Scientific Reports·Sébastien de MaistreJean-Eric Blatteau
Jan 27, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Henry T PengShawn G Rhind
Jan 18, 2019·Journal of Applied Physiology·Rongjia ZhangXuejun Sun
Oct 24, 2009·Journal of Applied Physiology·Jean-Michel PontierLionel Bourdon
Sep 28, 2013·Journal of Applied Physiology·Nicolas ValléeJean-Eric Blatteau
May 20, 2020·Scientific Reports·Marina ArreguiYara Bernaldo de Quirós
Feb 11, 2012·Journal of Applied Physiology·Nicolas ValleeJean-Eric Blatteau
May 26, 2018·Journal of Intensive Care·Asadullah Naqvi, Derrick Clarence
Mar 17, 2018·Frontiers in Physiology·Aleksandra MazurFrançois Guerrero

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