PMID: 2104674Jan 1, 1990Paper

Blood platelets and schistosome egg excretion

Proceedings of the Society for Experimental Biology and Medicine
J R Ngaiza, M J Doenhoff

Abstract

The eggs of helminths of the Schistosoma genus require to be extravasated in order to continue the life cycle of the parasite. The possible mode by which this takes place was investigated in a mouse model. Suppression of platelet activity in Schistosoma mansoni-infected mice by administering rabbit anti-mouse platelet serum or a selection of "antiplatelet drugs" resulted in a significant reduction of parasite egg excretion. This reduction was best achieved when antiplatelet agents were administered just before the onset of parasite egg excretion. The association between parasite eggs and platelets was illustrated in vivo and in vitro where platelet aggregates on egg surfaces were seen in both light and electron microscopy. In addition, eggs that had been isolated from infected mouse tissues induced platelet aggregation in whole mouse blood, and this was inhibited by preincubation with the beta-lactam antibiotic, ticarcillin. Isolated eggs were also capable of inducing ex vivo platelet aggregation in mice, which was dependent on presensitization with eggs. These data suggest a role for platelets in the extravasation and excretion of parasite eggs in schistosomiasis.

Citations

Dec 1, 1990·Cancer Metastasis Reviews·M J DoenhoffJ Modha
May 26, 2004·Parasite Immunology·Ronald G StanleyMichael J Doenhoff
Aug 16, 2011·Experimental Parasitology·Saskia deWalickJaap J van Hellemond
Jun 29, 2011·Experimental Parasitology·Maarten HulstijnJosé Roberto Machado-Silva
Feb 25, 2014·International Journal for Parasitology·Saskia DewalickJaap J van Hellemond
Jul 3, 2002·Nature Reviews. Immunology·Edward J Pearce, Andrew S MacDonald
Nov 22, 2018·Frontiers in Immunology·Christian Schwartz, Padraic G Fallon
Jun 13, 2019·Diseases of Aquatic Organisms·Phoebe A ChapmanPaul C Mills
Sep 22, 2007·Journal of Thrombosis and Haemostasis : JTH·Y P WuJ J van Hellemond
Jan 9, 2019·Frontiers in Immunology·Alice H CostainHermelijn H Smits

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