Blood pressure and all-cause mortality among patients with type 2 diabetes

International Journal of Cardiology
Weiqin LiGang Hu

Abstract

The recommended goal for blood pressure (BP) control has recently been adjusted for people with diabetes, but the optimal BP control range for the diabetic population is still uncertain. We performed a prospective cohort study of 35,261 patients with type 2 diabetes. Cox proportional hazard regression models were used to estimate the association of BP with all-cause mortality. During a mean follow-up period of 8.7 years, 4199 deaths were identified. The multivariable-adjusted hazard ratios of all-cause mortality associated with different levels of systolic/diastolic BP (<110/65, 110-119/65-69, 120-129/70-80, 130-139/80-90 [reference group], 140-159/90-100, and ≥160/100 mmHg) were 1.70 (95% confidence interval [CI] 1.42-2.04), 1.26 (95% CI 1.07-1.50), 0.99 (95% CI 0.86-1.12), 1.00, 0.92 (95% CI 0.82-1.03), and 1.10 (95% CI 0.98-1.23) using baseline BP measurements, and 2.62 (95% CI 2.00-3.44), 1.77 (95% CI 1.51-2.09), 1.22 (95% CI 1.09-1.36), 1.00, 0.90 (95% CI 0.82-1.00), and 0.98 (95% CI 0.86-1.12) using an updated mean value of BP during follow-up, respectively. The U-shaped associations were confirmed in both African American and white patients, in both men and women, in those who were or were not taking antihypertensive dru...Continue Reading

References

Jun 3, 2005·Journal of the American Society of Nephrology : JASN·Tomas BerlUNKNOWN Collaborative Study Group
May 30, 2008·Endocrine-related Cancer·Xilin YangPeter C Y Tong
Oct 20, 2009·Journal of Hypertension·Giuseppe ManciaUNKNOWN European Society of Hypertension
Mar 17, 2010·The New England Journal of Medicine·William C CushmanFaramarz Ismail-Beigi
Jul 8, 2010·JAMA : the Journal of the American Medical Association·Rhonda M Cooper-DeHoffCarl J Pepine
Jul 14, 2010·Age and Ageing·Kornelis J J van HaterenHenk J G Bilo
Sep 6, 2011·Diabetes Research and Clinical Practice·Wei LiGang Hu
May 30, 2013·The Journal of Clinical Endocrinology and Metabolism·Wenhui ZhaoGang Hu

❮ Previous
Next ❯

Citations

Apr 26, 2016·International Journal of Cardiology·Katsunori NonogakiNariki Kubota
Mar 25, 2019·The Journal of Clinical Endocrinology and Metabolism·Derek LeRoithAlan J Sinclair
Aug 6, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Chao-Lei ChenYing-Qing Feng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.