Blood pressure and cardiovascular reflex development in fetal sheep. Relation to hypoxaemia, weight, and blood glucose

Reproduction, Fertility, and Development
C CroweM A Hanson

Abstract

We measured mean arterial blood pressure (MAP), fetal heart rate (FHR), the baroreflex, weight, blood gases, blood glucose and lactate in chronically instrumented fetal sheep for 14 days from Day 105 to Day 109 gestation, with or without daily administration of 1 h of acute isocapnic hypoxaemia (arterial O2 partial pressure, PaO2, 11-13 mm Hg; 1 mm Hg = 133 Pa). Fetuses subjected to hypoxia showed no significant differences in MAP or FHR v. control fetuses. However, examination of all fetuses together revealed that there were two distinct groups: those showing a rise in MAP over the 14 days ('pressure up' group, PU), and those in which blood pressure did not increase or showed only a slight decrease ('pressure down' group, PD). PU fetuses were proportionately larger than PD fetuses. In contrast to PU fetuses, PD fetuses had lower blood glucose concentration, arterial O2 saturation (SaO2), PaO2, total haemoglobin, haematocrit and oxygen content, and higher lactate concentration, pH and PaCO2. PU fetuses showed a shift of the baroreflex MAP/R-R interval curve to the right, however, the PD group showed a shift upwards from Day 1 to Day 14. The PD group responded to hypoxia with a greater increase in MAP than the PU group. Thus, re...Continue Reading

Citations

Feb 3, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M A Hanson
Jul 31, 1998·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·M A Hanson
Mar 26, 2004·American Journal of Obstetrics and Gynecology·Juanita K JellymanDino A Giussani
Sep 8, 1998·The Journal of Physiology·C Steyn, M A Hanson
May 4, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Catalina HutanuCharles R Rosenfeld
Oct 4, 2011·Molecular and Cellular Biochemistry·Ruchi SharmaAkhtar Mahmood
Jun 29, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Laura BennetAlistair J Gunn
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P HawkinsM A Hanson

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