PMID: 2874032Jan 1, 1986Paper

Blood pressure and catecholamines following exercise during selective beta-blockade in hypertension

European Journal of Clinical Pharmacology
R VandongenP Rogers


This study examines and compares the hemodynamic and sympathoadrenal response to bicycle exercise in hypertensive subjects during two weeks' treatment with a cardio-selective (metoprolol) and nonselective (propranolol) beta-blocker. The increase in plasma norepinephrine and epinephrine concentration following exercise was augmented to a similar degree with each beta-blocker. Pre-exercise blood pressure and heart rate were similar for the two drugs. However immediately after exercise and particularly after resting for 20 min post exercise, diastolic blood pressure was lower during metoprolol treatment. Systolic blood pressure was also lower 20 min post exercise during metoprolol treatment. These observations indicate that cardio-selective beta-blockers offer advantages in blood pressure control during exercise through intact vascular beta 2-adrenoceptors opposing sympathetically mediated vasoconstriction.


Jun 1, 1978·European Journal of Clinical Investigation·K H RahnW Stephany
Dec 28, 1977·European Journal of Clinical Pharmacology·C L van HerwaardenA van't Laar
Jul 23, 1971·Brain Research·J Westman, D Bowsher
Sep 1, 1981·British Journal of Clinical Pharmacology·M EslerG Jennings


Jan 1, 1990·European Journal of Clinical Pharmacology·S FrankM Kohnle
Jan 1, 1990·Pharmacology & Therapeutics·J McAinsh, J M Cruickshank

Related Concepts

Adrenergic beta-Antagonists
Diastolic Blood Pressure
Epinephrine Acetate
Pulse Rate
Hypertensive Disease
Norepinephrine, (+, -)-Isomer

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