Blood pressure and heart rate development in young spontaneously hypertensive rats

The American Journal of Physiology
J G Dickhout, R M Lee

Abstract

The course of hypertension development in young spontaneously hypertensive rats (SHR) was studied by the measurement of changes in systolic blood pressure (BP), body weight, and heart rate (HR) at 2, 3, 4, and 6 wk of age. To achieve this, we compared inbreeding lines of SHR and Wistar-Kyoto rats (WKY) to determine if differences in BP, body weight, or HR were present among inbreeding lines of the same strain or between strains. The effect of these differences on the eventual level of BP was then assessed. We found that BP began to diverge between SHR and WKY at 4 wk of age. Significant differences in systolic BP (24 mmHg) between SHR inbreeding lines at 4 wk of age did not affect the BP at 8 wk (172 vs. 170 mmHg). Pulse pressure was significantly higher in SHR than in WKY at 4 wk of age. HR was elevated in SHR over age-matched WKY at 3 wk of age and positively correlated to the level of BP attained by individual animals at 6 wk (P = 0.037). Moreover, WKY inbreeding lines showing elevated HR developed higher BP (145 vs. 127 mmHg) at 10-12 and 20 wk of age. The prehypertensive tachycardia in SHR was investigated further and found to result from an increased intrinsic HR. Because HR at 3 wk is a genetic trait that can be partitio...Continue Reading

References

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Citations

Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J G Dickhout, R M Lee
Aug 7, 2002·British Journal of Pharmacology·Klaus HöcherlArmin Kurtz
Apr 16, 2011·Journal of Applied Physiology·Matthew J CatesJulian F R Paton
Aug 1, 2012·Physiological Research·Z CharvátováB Ošt'ádal
Jul 15, 2015·The Laryngoscope·Greice Anne Rodrigues da SilvaValéria Paula Sassoli Fazan
Jul 19, 2016·Physiological Research·P Konopelski, M Ufnal
Apr 11, 2019·American Journal of Physiology. Renal Physiology·Te-Jung LuTe Ling Lu
Oct 30, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Beatriz Gálvez-PrietoMaria S Fernández-Alfonso
Jun 7, 2011·American Journal of Physiology. Heart and Circulatory Physiology·M Victoria CondeSilvia M Arribas
Jul 2, 2010·Experimental Physiology·Jasenka Zubcevic, Jeffrey T Potts
Sep 12, 2014·BioMed Research International·Shin-ichiro KatsudaTsuyoshi Shimizu
Jun 30, 2019·Canadian Journal of Physiology and Pharmacology·Valentina Sophia RumanovaMichal Zeman
Mar 7, 2020·Clinical and Experimental Pharmacology & Physiology·Takahiro ShimizuMotoaki Saito
Mar 9, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Safaa NaielJeffrey G Dickhout
Sep 25, 2017·Noise & Health·Anne T M KonkleDavid Michaud
Jul 28, 2020·Journal of Food Biochemistry·Pema RajThomas Netticadan
Aug 4, 2020·European Journal of Pharmacology·Luísa Nathália Bolda MarianoPriscila de Souza

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