PMID: 6160941Dec 1, 1980Paper

Blood pressure and heart rate responses to centrally administered substance P are increased in spontaneously hypertensive rats

Clinical Science
T UngerD Ganten

Abstract

1. The cardiovascular effects after intracerebroventricular injections of substance P were investigated in normotensive Wistar-Kyoto and in spontaneously hypertensive rats. 2. Substance P increased blood pressor in both rat strains. Wistar-Kyoto rats responded with moderate, dose-dependent blood pressure increases, and heart rate decreased; spontaneously hypertensive rats showed two- to three-fold increased pressor effects and, concomitantly, marked heart rate increases to intracerebroventricular injections of substance P. 3. Sino-aortic baroreceptor denervation rendered Wistar-Kyoto rats supersensitive to intracerebroventricular substance P to a similar degree as unoperated spontaneously hypertensive rats. Sino-aortic denervation had no effect on the blood pressure responses to the peptide in spontaneously hypertensive rats. 4. The central pressure actions of substance P could be markedly attenuated by intracerebroventricular pretreatment with the derivative of gamma-aminobutyric acid, baclofen. 5. We conclude that the baroreceptor reflex is disturbed in spontaneously hypertensive rats. Substance P may contribute to the pathogenesis of hypertension. The effector pathways appear to be different from angiotensin.

Citations

Dec 29, 1995·Annals of the New York Academy of Sciences·J CulmanT Unger
Aug 1, 1985·Clinical Physiology·J H HenriksenO B Schaffalitzky De Muckadell
Oct 1, 1984·Multivariate Behavioral Research·W R Dillon, N Mulani
Jul 1, 1995·Canadian Journal of Physiology and Pharmacology·J Culman, T Unger
Mar 1, 2000·British Journal of Pharmacology·S S Ng, C C Pang
Oct 3, 2001·Physiological Reviews·H E de Wardener

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