PMID: 6109798Jan 17, 1981Paper

Blood pressure and hormonal changes following alteration in dietary sodium and potassium in young men with and without a familial predisposition to hypertension

Lancet
P S ParfreyJ M Ledingham

Abstract

The blood pressures (BP) of the parents of a group of students were determined and two subgroups of students were defined, one with (PHT group) and one without (PNT group) a familial predisposition to hypertension. Observations were made in both groups during three periods of modified dietary electrolyte intake: (i) no-added sodium (low Na), (ii) no added sodium with potassium supplementation (low Na/high K), and (iii) sodium supplementation (high Na). The diets were given in random order. At the start of the trial, while the students continued their customary diet, the PHT group had higher systolic and diastolic pressures and plasma noradrenaline levels than the PNT group. At the end of 4 weeks of the high Na diet, the BP levels of both groups were significantly higher than those after the low Na diet. In contrast, when the low Na diet was supplemented for 2 weeks with potassium, BPs of the PHT group fell significantly, while those of the PNT group rose slightly. BP in the PHT group was significantly lower during the low Na/high K than during the high Na diet (systolic 10.5 mm Hg +/- 2.3 SE; diastolic 11.2 +/- 2.5, the changes being significantly different from those in the PNT group. The changes in plasma renin and aldosteron...Continue Reading

Citations

Jan 1, 1982·Journal of the American College of Nutrition·M H WeinbergerC E Grim
Jan 1, 1983·Current Medical Research and Opinion·R I Ogilvie
May 2, 2013·The Cochrane Database of Systematic Reviews·Feng J HeGraham A Macgregor
Jul 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S HeydenK A Schneider
Jul 1, 1982·Archives of Environmental Health·B K ArmstrongM G McCall
Jan 7, 2015·Pflügers Archiv : European journal of physiology·David PentonJohannes Loffing
Jul 1, 1983·Hypertension·D E AndersonT J Worden
Apr 10, 2017·The Cochrane Database of Systematic Reviews·Niels Albert GraudalGesche Jurgens
Jan 1, 1986·Journal of the American College of Nutrition·F C LuftN S Fineberg
Aug 16, 2016·Frontiers in Physiology·Holly Digne-MalcolmKeith L Dorrington
Dec 15, 2020·The Cochrane Database of Systematic Reviews·Niels Albert GraudalGesche Jurgens
Jun 30, 2021·Experimental Physiology·Keith L Dorrington, Matthew C Frise

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