Abstract
To investigate the effects of dietary sodium restriction from conception to adulthood on blood pressure and its regulatory mechanisms, male offspring were derived from inbreeding in spontaneously hypertensive rats fed a diet containing sodium of 175 mumol/g food (control) or 22 mumol/g (low sodium), which is the least sodium content for normal growth. While urinary sodium excretion was markedly less, the low sodium diet did not inhibit body growth and failed to blunt the development of hypertension. Neither plasma catecholamine concentration nor depressor response to hexamethonium was different between the two groups at any age examined (8, 12, and 20 weeks). Plasma renin concentration was not elevated, whereas urinary excretion of aldosterone was increased at any age in the low sodium group compared with that in the control group. Other sets of rats were fed a diet containing sodium of 175 mumol/g plus mefruside (a diuretic) of 0.001% in the same manner as in the other two groups. Urinary sodium excretion per creatinine was higher than in the other groups. The diuretic treatment inhibited body growth and suppressed adult blood pressure. While the sympathetic function was not affected, both plasma renin concentration and urinar...Continue Reading
References
Jun 1, 1976·Circulation Research·W V JudyG M Hockel
Apr 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·V Karr-Dullien, E Bloomquist
Sep 1, 1977·Life Sciences·J D Peuler, G A Johnson
Apr 1, 1991·Journal of Hypertension·S AzarC Bingham
Aug 1, 1990·American Journal of Hypertension·D L ElyN F Paradise
Feb 1, 1990·Hypertension·R Di NicolantonioT O Morgan
Jan 1, 1989·Journal of Hypertension·F H Leenen, C B Toal
Feb 1, 1987·Journal of Hypertension·C B Toal, F H Leenen
Aug 10, 1987·Life Sciences·E A Wilczynski, F H Leenen
Dec 1, 1986·Hypertension·J ZichaJ Jelínek
Aug 1, 1987·Journal of Hypertension·B Folkow, D L Ely
Sep 1, 1987·Clinical Cardiology·N KawazoeY Tomita
May 1, 1985·Clinical and Experimental Pharmacology & Physiology·S B Harrap, A E Doyle
Dec 11, 1971·Lancet·W J LouisS Spector
Jan 1, 1974·Drugs·R N BrogdenG S Avery
Sep 1, 1984·Hypertension·L A FerraraM Mancini
Jun 1, 1984·Journal of Autonomic Pharmacology·R R Vollmer
May 20, 1984·Nihon Naibunpi Gakkai zasshi·T KawasakiT Omae
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·S R Winternitz, S Oparil
Nov 1, 1982·Hypertension·W H BeierwaltesP J Klemmer
Mar 16, 1981·Life Sciences·G L WrightB C Wexler
Oct 1, 1993·Hypertension·R A Hunt, D C Tucker
Apr 1, 1962·The Journal of Clinical Investigation·A GROLLMAN, E F GROLLMAN
May 1, 1962·The American Journal of Physiology·L TOBIAND FERREIRA
Citations
Jan 15, 1999·Clinical and Experimental Pharmacology & Physiology·I Gouldsborough, N Ashton
Feb 15, 2013·PloS One·Chee-Meng BoonShiueh-Lian Mok
Nov 1, 2005·European Journal of Pharmacology·Kazuhito HayakawaYukio Yamori
Oct 3, 1999·Physiological Reviews·J Zicha, J Kunes