PMID: 40797Jul 1, 1979

Blood pressure and plasma noradrenaline during single high-dose beta adrenoceptor blockade

European Journal of Clinical Pharmacology
T J MalingC T Dollery

Abstract

The acute effects upon blood pressure and sympathetic outflow of two beta adrenoceptor blocking drugs, propranolol and atenolol, are described in five healthy normotensive subjects. Supine blood pressure, heart rate, plasma noradrenaline, and urinary catecholamine excretion were measured before and at intervals for 24 h after a single oral dose of either propranolol 200 mg, atenolol 100 mg, or placebo. Propranolol caused a fall in blood pressure and heart rate of 17.2/14.1 mm Hg and 20.4 beats/min respectively two hours after dose. Atenolol caused a fall in blood pressure of 11.4/18.6 mm Hg within 7 h of the dose, and a fall in heart rate of 13.8 beats/min after 2 h. The reduction in blood pressure after single high dose beta adrenoceptor blockade is established. The synchronous reduction in blood pressure and heart rate after propranolol was not associated with an increase in peripheral sympathietic activity as assessed by the biochemical indices. It is conceivable that the reduction in blood pressure during beta adrenoceptor blockade may be due in part to inappropriately low sympathetic activity but this cannot be the main mechanism of pressure reduction.

References

Jan 1, 1983·Pharmacology & Therapeutics·A J Scriven, P J Lewis
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·J D Fitzgerald
Dec 1, 1985·British Journal of Clinical Pharmacology·P C O'ConnorR G Shanks
Jun 1, 1984·British Journal of Clinical Pharmacology·F H LeenenE J Dorhout Mees
Oct 1, 1981·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H P Illing, E S House
May 1, 1982·Clinical Cardiology·D T O'Connor, R A Preston

Citations

Feb 1, 1975·Life Sciences·D P HenryR H Williams
Feb 1, 1972·The Journal of Clinical Endocrinology and Metabolism·A M Michelakis, R G McAllister
May 1, 1973·British Heart Journal·P A MajidS H Taylor
Mar 1, 1968·Circulation·E D FrohlichI H Page
Jan 4, 1969·British Medical Journal·B N PRICHARD, P M Gillam
Feb 1, 1961·Acta Physiologica Scandinavica·U von EULER, F LISHAJKO
May 9, 1964·British Medical Journal·B N PRICHARD

Related Concepts

Diastolic Blood Pressure
Norepinephrine, (+, -)-Isomer
Beta Adrenoceptor Activity
Norepinephrine
Norepinephrine Measurement
Propranolol
Blood Pressure
Atenolol
Catecholamines
Block Drugs

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.