Blood pressure augmentation and maternal circulating concentrations of angiogenic factors at delivery in preeclamptic and uncomplicated pregnancies.

American Journal of Obstetrics and Gynecology
Rebecca TroisiAnne Cathrine Staff

Abstract

The objective of the study was to determine whether blood pressure increases are associated with maternal angiogenic factors in uncomplicated and preeclamptic pregnancies. Associations of blood pressure increases from mid- to late pregnancy with maternal serum concentrations of soluble fms-like tyrosine kinase receptor (sFlt1), soluble endoglin (sEng), and placental growth factor (PlGF) at delivery were analyzed in 43 uncomplicated and 44 preeclamptic pregnancies. In uncomplicated pregnancies, increases in diastolic and mean arterial pressure were inversely associated with PlGF at delivery and positively associated with sEng and sFlt1/PlGF ratio. There were no significant associations between blood pressure increases and angiogenic factor concentrations in preeclampsia. These data suggest that angiogenic factors are involved in blood pressure modulation in normotensive pregnancy and are consistent with the hypothesis that angiogenic balance plays a role in maternal breast cancer risk reduction associated with mid- to late blood pressure increases in uncomplicated pregnancies.

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Citations

Jun 7, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jessica M Faupel-BadgerRebecca Troisi
Mar 11, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Lene G RasmussenAnne C Staff
Jan 13, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Anne Cathrine StaffRebecca Troisi
Aug 11, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tinnakorn ChaiworapongsaSonia S Hassan
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Sep 18, 2012·American Journal of Obstetrics and Gynecology·Thomas F McElrathSamuel Parry
Oct 18, 2011·American Journal of Obstetrics and Gynecology·Stefan VerlohrenHolger Stepan
Dec 2, 2014·American Journal of Obstetrics and Gynecology·Jessica M Faupel-BadgerRebecca Troisi
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Apr 26, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ana JakovljevicGorana Mitic
Nov 28, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nnabuike C Ngene, Jagidesa Moodley
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Dec 7, 2018·Cancer Causes & Control : CCC·Rosie CornishRebecca Troisi
Feb 3, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Georgia Margioula-SiarkouGeorgios Mavromatidis
Dec 31, 2020·International Journal of Molecular Sciences·Lucía Pérez-RoqueMiguel Pericacho

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