Blood pressure components and cardiovascular events in older adults: the Rotterdam study

Journal of the American Geriatrics Society
Francesco U S Mattace-RasoJ C M Witteman

Abstract

To compare the strength of the relative risks of systolic (SBP) diastolic blood pressure (DBP) and pulse pressure (PP) as predictors of myocardial infarction and stroke in older adults. Prospective cohort study. The Rotterdam Study, a Dutch population-based study. A total of 4,234 subjects aged 55 and older with no previous myocardial infarction (MI) or stroke at baseline. Blood pressure levels at baseline, first MI and stroke, all-cause mortality during follow-up. During follow-up, 205 subjects had an MI (average follow-up period 7 years), 137 subjects had a stroke (average follow-up period 6.1 years), and 748 subjects died. A 1-standard deviation difference in SBP, DBP, and PP was associated with relative risks of MI of 1.24 (95% confidence interval (CI)=1.06-1.46), 1.07 (0.92-1.25), and 1.25 (1.07-1.48), respectively. Corresponding relative risks for stroke were 1.59 (1.37-1.86), 1.27 (1.10-1.48), and 1.48 (1.27-1.72). For all-cause mortality the corresponding relative risks and 95% CI were 1.21 (1.11-1.31), 1.06 (0.99-1.14), and 1.20 (1.10-1.31). The results of this study suggest that, in a population of apparently healthy older adults, PP is not a better predictor of cardiovascular events and all-cause mortality than SBP.

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Citations

Sep 17, 2011·American Journal of Alzheimer's Disease and Other Dementias·Yuan-Han YangJohn C Morris
Feb 6, 2013·International Journal of Environmental Research and Public Health·Lisa A MatriccianiMark Daniel
Jun 27, 2009·Clinics in Geriatric Medicine·William J Mosley, Donald M Lloyd-Jones
Aug 5, 2005·Journal of the American Geriatrics Society·Alexander A FisherMarc M Budge
Sep 6, 2007·The Journal of Clinical Hypertension·Shizukiyo IshikawaUNKNOWN Jichi Medical School (JMS) Cohort Study Group
Sep 6, 2005·Primary Care·Michael MaddensAyham Ashkar
Aug 15, 2006·Journal of the American College of Cardiology·Ilke SipahiSteven E Nissen
Sep 1, 2006·American Journal of Hypertension·Carmen A PeraltaMichael G Shlipak
Feb 8, 2006·Circulation·Francesco U S Mattace-RasoJacqueline C M Witteman
May 9, 2014·Journal of the American Heart Association·Justin P ZachariahGary F Mitchell
May 11, 2016·Hypertension·Marileen L P PortegiesM Arfan Ikram
Dec 13, 2005·Stroke; a Journal of Cerebral Circulation·Michael H FreitagLenore J Launer
Apr 9, 2020·Journal of Human Hypertension·Dechen LiuJie Lu

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