Blood pressure control early in diabetes: a balance between angiotensin II and nitric oxide

Clinical and Experimental Pharmacology & Physiology
M W Brands, Sharyn M Fitzgerald

Abstract

1. Hyperglycaemia can lead to hypertension in long- standing diabetes through cumulative effects to cause progressive glomerular injury. However, it is not known how hyperglycaemia directly affects blood pressure control. Moreover, it has been difficult to isolate the actions of hyperglycaemia from other factors that can influence blood pressure. Recent studies at the earliest stages of type I diabetes have started to address these issues. 2. In humans and in animal models of type I diabetes, there is evidence that onset of hyperglycaemia can increase blood pressure. The increase is mild and has been linked to angiotensin (Ang) II, possibly due to slight overstimulation of the system in response to hyperglycaemia. 3. We have reported recently that onset of hyperglycaemia causes severe hypertension in rats that are treated chronically with N(G)-nitro-L-arginine methyl ester and the hypertension is accompanied by a progressive increase in AngII and absence of hyperfiltration. This suggests that nitric oxide (NO), at the early stages of diabetes, is important in mediating the increase in glomerular filtration rate and in preventing hypertension. 4. We propose a hypothesis based on these results that hyperglycaemia at the earliest ...Continue Reading

References

May 1, 1979·The American Journal of the Medical Sciences·A R ChristliebR H Underwood
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H VlassaraR Bucala
Feb 1, 1991·American Journal of Hypertension·J R SowersM Zemel
Jun 1, 1984·Diabetologia·C Hellerström
Nov 1, 1981·Kidney International·C B WilsonR C Blantz
Oct 1, 1994·Diabetes·L A SechiM Schambelan
Dec 1, 1993·Journal of the American Society of Nephrology : JASN·J E KalinyakM Schambelan
Feb 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T H Hostetter
Aug 1, 1993·The American Journal of Physiology·B S McAllisterM S Olson
Mar 1, 1996·Hypertension·M W Brands, T E Hopkins
Dec 1, 1996·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·M E Cooper
Nov 5, 1997·American Journal of Hypertension·E RitzK Strojek
Mar 14, 1998·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·W F GraierG M Kostner
Sep 18, 1998·Hypertension·M W Brands, S M Fitzgerald
Aug 14, 1999·Journal of the American Society of Nephrology : JASN·J A Miller
Feb 9, 2000·American Journal of Physiology. Renal Physiology·G C SchoonmakerP K Carmines
Feb 26, 2000·Acta Physiologica Scandinavica·L G NavarJ D Imig
Apr 26, 2000·American Journal of Physiology. Endocrinology and Metabolism·M W BrandsA E Hailman
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·S M Fitzgerald, M W Brands
Sep 28, 2000·Canadian Journal of Physiology and Pharmacology·R Tatchum-TalomJ R McNeill
Mar 30, 1963·Lancet·J G BORST, A BORST-DE GEUS

❮ Previous
Next ❯

Citations

Feb 1, 2006·Clinical and Experimental Pharmacology & Physiology·Zhaoping LiuChangxing Liu
Sep 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Emaad M Abdel-RahmanHelmy M Siragy
Oct 19, 2007·American Journal of Nephrology·Daniela B VidottiMirian A Boim
Oct 15, 2013·Clinical and Experimental Pharmacology & Physiology·Syed QuadriKeith E Jackson
Mar 18, 2006·Nephron. Physiology·Ildikó TomaJános Peti-Peterdi
Aug 6, 2004·Endocrine Reviews·Zhi You FangThomas H Marwick

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

Japanese Journal of Pharmacology
Alex F ChenChao-Yu Miao
Journal of Diabetes and Its Complications
Alain D Baron
Clinical and Experimental Pharmacology & Physiology
Harvey R WeissPeter M Scholz
© 2022 Meta ULC. All rights reserved