PMID: 11918510Mar 29, 2002Paper

Blood pressure elevation in a patient treated with salsalate

The Annals of Pharmacotherapy
Beth Bryles PhillipsPaul L Mulhausen

Abstract

To report a case of increased blood pressure associated with the use of salsalate in an elderly patient with no prior history of hypertension. A 78-year-old white man with no prior history of hypertension initiated salsalate therapy for low-back pain. Over the 15 months prior to the initiation of salsalate, his blood pressure averaged 127 +/- 7 mm Hg systolic and 84 +/- 6 mm Hg diastolic (mean +/- SD). After initiation of salsalate, he experienced significant elevations in blood pressure, which led to a preliminary diagnosis of hypertension. Blood pressure after initiation of salsalate averaged 150 +/- 13 mm Hg systolic and 95 +/- 5 mm Hg diastolic. No changes in medications or medication doses (with the exception of warfarin) occurred in the 18 months prior to or during salsalate therapy. His weight remained stable. A detailed review of his medical records and history revealed no other causes for these elevations in blood pressure. Salsalate therapy was discontinued and his blood pressure returned to normotensive levels (119 +/- 2 mm Hg systolic and 81 +/- 2 mm Hg diastolic). Nonsteroidal antiinflammatory drug (NSAID)-induced elevations in blood pressure have been well documented in patients receiving antihypertensive medicati...Continue Reading

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Citations

Mar 21, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·UNKNOWN Japanese Society of Hypertension
Nov 13, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·S TrifilioJ Mehta

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