Blood pressure in children and adolescents with Cushing's syndrome before and after surgical care

The Journal of Clinical Endocrinology and Metabolism
M A MagiakouG P Chrousos

Abstract

Approximately half of children and adolescents with Cushing's syndrome develop hypertension. To examine the role of hypercortisolism in the pathogenesis of hypertension in young patients and to establish its reversibility, we studied 31 hypertensive children and adolescents with Cushing's syndrome (systolic, diastolic, and/or mean blood pressure more than 2 SD U for age and sex) from a total of 63 patients before, and for a period of 1 yr after surgical cure. Preoperatively, 93.5%, 42%, and 45% of these patients presented with an increase of the systolic, diastolic, and mean blood pressure, respectively. The systolic blood pressure remained increased in 30.7%, 15.8%, and 5.5% of patients at 3, 6, and 12 months after surgical cure, respectively. The diastolic and mean blood pressure completely normalized by 3 months after surgical cure. A significant, positive correlation was observed between the systolic blood pressure and the duration of the disease, but no correlation was seen with the 24-h urinary free cortisol values and/or the patients' body mass indices. The lack of correlation between 24-h urinary free cortisol values and blood pressure suggests that hypercortisolism influences blood pressure through multiple pathways. T...Continue Reading

References

Feb 1, 1979·Pediatric Clinics of North America·S A Kaplan
Feb 1, 1991·The Journal of Pediatrics·M T GomezG P Chrousos
Sep 15, 1988·Annals of Internal Medicine·T J MampalamC B Wilson
Feb 1, 1986·The Journal of Clinical Endocrinology and Metabolism·T SarutaS Senba
Feb 1, 1987·Journal of Neurosurgery·W F ChandlerG Ibarra-Perez
Apr 1, 1986·The Journal of Clinical Investigation·R UdelsmanG P Chrousos
Jan 1, 1985·Cardiology·D K Lüdecke, G Niedworok
Mar 1, 1968·The Journal of Clinical Endocrinology and Metabolism·B E Murphy
Jun 1, 1969·Archives of Disease in Childhood·W A Marshall, J M Tanner
Jul 1, 1982·Disease-a-month : DM·D T Krieger
Aug 1, 1983·Journal of Neurosurgery·J E BogganC B Wilson
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·L RuilopeJ L Rodicio
Nov 23, 1995·The New England Journal of Medicine·L L BronnerJ E Manson
Jun 1, 1995·Australian and New Zealand Journal of Medicine·E G Stewart-Wynne, K Jamrozik
Sep 8, 1994·The New England Journal of Medicine·M A MagiakouG P Chrousos
Apr 1, 1994·Clinical Endocrinology·J Etxabe, J A Vazquez
Jan 1, 1993·Clinical and Experimental Hypertension : CHE·E E SoltisL A Cassis
Sep 1, 1995·International Journal of Cardiology·R BeegomR B Singh
Dec 29, 1995·Annals of the New York Academy of Sciences·P M Peeke, G P Chrousos
Mar 1, 1990·Environmental Geochemistry and Health·J A Edwardson, J M Candy

❮ Previous
Next ❯

Citations

May 6, 2009·European Journal of Pediatrics·Maya LodishConstantine A Stratakis
Jan 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Jil Huong NguyenConstantine A Stratakis
Mar 19, 2009·The Journal of Clinical Endocrinology and Metabolism·Maya B LodishConstantine A Stratakis
Jun 2, 2012·Journal of Endocrinological Investigation·G ArnaldiM Boscaro
Apr 4, 2002·Journal of Endocrinological Investigation·M A Magiakou, G P Chrousos
Nov 6, 2004·Current Hypertension Reports·Smita Baid, Lynnette K Nieman
May 14, 2011·Endocrinology and Metabolism Clinics of North America·Susmeeta T Sharma, Lynnette K Nieman
Jul 27, 2010·General and Comparative Endocrinology·Pascale SmetsSylvie Daminet
May 14, 2016·European Journal of Pediatrics·Maria GüemesMehul T Dattani
Nov 11, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bryan G HelwigMichael J Kenney
Oct 22, 2009·Nature Reviews. Endocrinology·John Newell-Price
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Rosario PivonelloAnnamaria Colao
May 4, 2013·The Journal of Clinical Endocrinology and Metabolism·Margaret F Keil
Mar 18, 2000·Journal of Chemotherapy·G U Meduri
Oct 31, 2019·The Journal of Clinical Endocrinology and Metabolism·German RubinsteinMartin Reincke
Jul 3, 2020·Journal of Veterinary Internal Medicine·Paula García San JoséMaría Dolores Pérez Alenza
Jan 21, 2010·Endocrine Reviews·Mark SherlockPaul M Stewart
Nov 14, 2019·Clinical Endocrinology·Smita JhaLynnette K Nieman
Jan 31, 2021·Reviews in Endocrine & Metabolic Disorders·Rosario FerrignoMartin O Savage
Dec 5, 2020·Journal of Veterinary Internal Medicine·Paula García San JoséMaría Dolores Pérez Alenza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved