Blood pressure interacts with APOE ε4 to predict memory performance in a midlife sample

Neuropsychology
Lauren E OberlinKirk I Erickson

Abstract

Elevated blood pressure and the Apolipoprotein ε4 allele (APOE ε4) are independent risk factors for Alzheimer's disease. We sought to determine whether the combined presence of the APOE ε4 allele and elevated blood pressure is associated with lower cognitive performance in cognitively healthy middle-aged adults. A total of 975 participants aged 30-54 (mean age = 44.47) were genotyped for APOE. Cardiometabolic risk factors including blood pressure, lipids, and glucose were assessed and cognitive function was measured using the Trail Making Test and the Visual Reproduction and Logical Memory subtests from the Wechsler Memory Scale. Multivariable regression analysis showed that the association between APOE ε4 and episodic memory performance varied as a function of systolic blood pressure (SBP), such that elevated SBP was predictive of poorer episodic memory performance only in APOE ε4 carriers (β = -.092; t = -2.614; p = .009). Notably, this association was apparent at prehypertensive levels (≥130 mmHg), even after adjusting for physical activity, depression, smoking, and other cardiometabolic risk factors. The joint presence of APOE ε4 and elevated SBP, even at prehypertensive levels, is associated with lower cognitive performanc...Continue Reading

Citations

Dec 29, 2017·Aging & Mental Health·Maureen Schmitter-EdgecombeKayela Robertson
Jan 7, 2017·Journal of the International Neuropsychological Society : JINS·Claire LancasterJennifer Rusted
Jan 11, 2018·Translational Psychiatry·Mark James RawleMarcus Richards

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