PMID: 3321926Jan 1, 1987Paper

Blood pressure is lowered by vitamin D (alphacalcidol) during long-term treatment of patients with intermittent hypercalcaemia. A double-blind, placebo-controlled study

Acta Medica Scandinavica
L LindS Ljunghall

Abstract

There is epidemiologic evidence of a relationship between calcium deficiency and hypertension. The present study evaluated the effects of alphacalcidol, a synthetic analogue of active vitamin D, given to 29 patients with marginal, intermittent hypercalcaemia. Before therapy there was an inverse relationship between serum calcium levels and diastolic blood pressure (p less than 0.02). Treatment with 1 microgram alphacalcidol raised the serum calcium by 0.07 mmol/l during a 6-month, double-blind, placebo-controlled trial and caused a significant reduction of diastolic blood pressure by 9.2 mmHg compared with placebo (p less than 0.01). The study extends previous observations, in normocalcaemic subjects, of inverse relationships between serum calcium and blood pressure indicating a primary disturbance of calcium homeostasis in hypertension. The observation that a physiologic amount of active vitamin D has hypotensive effects agrees with such a concept and suggests a new principle for the treatment of hypertension.

References

Oct 1, 1986·British Medical Bulletin·T B Bolton
May 1, 1987·European Heart Journal·S LjunghallL Lind
Aug 1, 1983·Clinical Science·P StrazzulloM Mancini
Jul 22, 1982·The New England Journal of Medicine·D A McCarron
Jul 16, 1982·Science·D A McCarronC Cole
Mar 1, 1958·British Journal of Urology·J HELLSTROMC A EDVALL

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Citations

Feb 26, 2005·Clinical Endocrinology·Leif Mosekilde
Jul 10, 2009·Journal of Hypertension·Miles D WithamAllan D Struthers
Sep 22, 2009·Arquivos brasileiros de endocrinologia e metabologia·Natielen Jacques SchuchLigia Araújo Martini
Jul 2, 2011·Journal of Hypertension·Robert ScraggCarlene M M Lawes
Apr 1, 2010·Nutrients·Vivian Cristina Garcia, Lígia Araújo Martini
Jul 6, 2010·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Elizabeth Pogge
Dec 19, 2012·Nature Reviews. Nephrology·Parta HatamizadehKamyar Kalantar-Zadeh
Jan 1, 1988·Scandinavian Journal of Urology and Nephrology·L LindS Ljunghall
Jan 1, 1991·Upsala Journal of Medical Sciences·L LindS Ljunghall
May 2, 2003·The British Journal of Nutrition·Armin Zittermann
Oct 19, 2017·Electrolyte & Blood Pressure : E & BP·Hye Yun JeongSo-Young Lee
Nov 22, 1997·Hypertension·E Kristal-BonehJ Ribak
Aug 19, 2009·Nature Reviews. Cardiology·Stefan PilzThomas R Pieber
Mar 5, 2013·European Journal of Epidemiology·Setor Kwadzo KunutsorMarinka Steur
Jan 15, 2014·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Jul 13, 2021·Cardiology Clinics·Parta Hatamizadeh
Jun 27, 2008·Molecular Aspects of Medicine·Jennifer S Buell, Bess Dawson-Hughes

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