Blood pressure level associated with lowest cardiovascular event in hypertensive diabetic patients

Journal of Hypertension
Chan Joo LeeSungha Park

Abstract

The ACCORD BP trial failed to show the benefit of strict blood pressure (BP) control on cardiovascular events in diabetics with high cardiovascular risk. However, this result cannot be generalized to all diabetics. We investigated whether lower mean BP in diabetic people with hypertension is associated with better prognosis. Participants from the Korea National Health Insurance Service Health Examinee Cohort who were diagnosed with diabetes and hypertension between 2003 and 2006 were included in the analysis (N = 7926). Mortality and cardiovascular events were compared among three groups according to mean SBP (<130, 130-<140, ≥140 mmHg) and mean DBP (<80, 80-<90, ≥ 90 mmHg) recorded during follow-up health examinations for up to 11 years. Significant reductions in the risk of all-cause death, nonfatal myocardial infarction (MI), nonfatal stroke, and end-stage renal disease were observed in patients with a mean SBP of 130 mmHg to less than 140 mmHg, as compared with patients with a mean SBP of at least 140 mmHg. The additional clinical benefit of a mean SBP of less than 130 mmHg was unclear. Lower risk of all-cause death, cardiovascular mortality, and nonfatal strokes was observed in patients with a mean DBP of 80 mmHg to less t...Continue Reading

References

Apr 20, 2005·Hypertension·Ji-Guang WangFrançois Gueyffier
Mar 17, 2010·The New England Journal of Medicine·William C CushmanFaramarz Ismail-Beigi
Jul 8, 2010·JAMA : the Journal of the American Medical Association·Rhonda M Cooper-DeHoffCarl J Pepine
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Nov 10, 2015·The New England Journal of Medicine·UNKNOWN SPRINT Research GroupWalter T Ambrosius
Jun 18, 2016·Journal of the American College of Cardiology·Min Jung KoDuk-Woo Park

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Citations

Jan 5, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Sang-Hyun IhmKwang Kon Koh

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