Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial

Phytotherapy Research : PTR
Fatemeh HomayouniKambiz Ahmadi

Abstract

Elevated levels of reactive oxygen species under diabetic condition lead to vascular complications and inflammation. This study aimed to examine the effects of hesperidin supplement on blood pressure and inflammatory markers in type 2 diabetes. In this research, 64 patients were randomly allocated to receive 500 mg/day hesperidin or placebo capsules for 6 weeks. Data on systolic blood pressure (SBP), diastolic blood pressure, serum total antioxidant capacity (TAC), tumor necrosis factor alpha, interleukin 6 (IL-6), and high-sensitivity C-reactive protein (hs-CRP) were collected at the baseline and at the end of the study. In the hesperidin group, SBP (122.7 ± 8.5 vs. 119.0 ± 7.4; p = .005), mean arterial blood pressure (94.2 ± 5.5 vs. 91.8 ± 5.5; p = .009), IL-6 (8.3 ± 2.1 vs. 7.4 ± 1.8; p = .001), and hs-CRP (1.9 ± 1.2 vs. 1.1 ± 0.9; p < .000) decreased whereas TAC increased (0.74 ± 0.1 vs. 0.82 ± 0.1; p < .000) in comparison to the baseline values. There was a significant difference in mean percent change of SBP, diastolic blood pressure, mean arterial blood pressure, serum TAC, and inflammatory markers (tumor necrosis factor alpha, IL-6, and hs-CRP) between hesperidin and control groups following intervention in adjusted mod...Continue Reading

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Citations

Apr 12, 2019·Phytotherapy Research : PTR·Hossein HasaniMaryam Miraghajani
Feb 6, 2020·Journal of Clinical Medicine·Teresa Caro-OrdieresJesús Egido
Apr 30, 2020·Experimental and Therapeutic Medicine·Mahmoud HashemzaeiJafar Shahraki
Jan 18, 2020·Anatomy & Cell Biology·Jeongtae KimTaekyun Shin
May 10, 2019·Frontiers in Immunology·Ana María Ruiz-LeónRosa Casas
Jun 2, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Masashi MiuraTakeshi Yatsushiro
Oct 27, 2020·Current Rheumatology Reports·Marina Bañuls-MireteMonica Guma
May 6, 2021·Natural Product Research·Alessio AlesciEugenia Rita Lauriano
Nov 19, 2021·Critical Reviews in Food Science and Nutrition·Yao ChenZhiyong He

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