Blood pressure lowering effects of rimonabant in obesity-related hypertension

Journal of Neuroendocrinology
G GrassiGiuseppe Mancia

Abstract

Obesity-related hypertension represents a common clinical condition characterised by complex pathophysiological and therapeutic features. From a pathophysiological view point, results of experimental and animal studies have led to the hypothesis that neurogenic mechanisms participate in the development and progression of the disease. The hypothesis is based on the evidence that metabolic (i.e. insulin-resistance) and neural (sympathetic activation) alterations frequently co-exist in the obese hypertensive patient and that they reciprocally potentiate each other. From a therapeutic view point, the 2007 European Society of Hypertension/European Society of Cardiology emphasised the importance in this clinical condition of treatment not only through antihypertensive drugs but also via lifestyle changes and drug-induced interventions that reduce body weight. The four Rimonabant In Obesity (RIO) studies have shown that rimonabant can decrease body weight. A recent meta-analysis, based on the RIO results, showed that rimonabant, particularly in obese hypertensive patients, can also decrease - although modestly (2.8 mmHg for systolic and 2.2 mmHg for diastolic) - blood pressure. These effects, which appear to be triggered by the weight...Continue Reading

References

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Citations

Jan 17, 2009·Current Hypertension Reports·Arya M Sharma
Jul 22, 2010·Annual Review of Nutrition·Vincenzo SavicaJoel D Kopple
Oct 31, 2017·Current Hypertension Reports·Revathy CarnagarinMarkus P Schlaich
Jan 22, 2009·Journal of Hypertension·Markus P SchlaichUNKNOWN Australian and New Zealand Obesity Society

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